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Trajectories of Postload Plasma Glucose in the Development of Type 2 Diabetes in Japanese Adults
- フォーマット:
- 論文
- 責任表示:
- Oka, Rie ; Shibata, Kyoko ; Sakurai, Masaru ; Kometani, Mitsuhiro ; Yamagishi, Masakazu ; Yoshimura, Kenichi ; Yoneda, Takashi ; 大家, 理恵 ; 柴田, 恭子 ; 櫻井, 勝 ; 米谷, 充弘 ; 山岸, 正和 ; 吉村, 健一 ; 米田, 隆
- 言語:
- 英語
- 出版情報:
- Hindawi Limited, 2017-09-14
- 著者名:
Oka, Rie Shibata, Kyoko Sakurai, Masaru Kometani, Mitsuhiro Yamagishi, Masakazu Yoshimura, Kenichi Yoneda, Takashi 大家, 理恵 柴田, 恭子 櫻井, 勝 米谷, 充弘 山岸, 正和 吉村, 健一 米田, 隆 - 掲載情報:
- Journal of Diabetes Research
- ISSN:
- 2314-6745
- 巻:
- 2017
- 開始ページ:
- 5307523
- バージョン:
- publisher
- 概要:
- 金沢大学附属病院研修医・専門医総合教育センター<br />We aimed to clarify how the trajectories of 1-hour postload plasma glucose (PG) and 2-hour PG were different in the development of type 2 diabetes. Using data of repeated health checkups in Japanese worker … s from April 2006 to March 2016, longitudinal changes of fasting, 1-hour, and 2-hour PG on the oral glucose tolerance test were analyzed with a linear mixed effects model. Of the 1464 nondiabetic subjects at baseline, 112 subjects progressed to type 2 diabetes during the observation period (progressors). In progressors, 1-hour PG and 2-hour PG showed gradual increases with slopes of 1.33 ± 0.2 and 0.58 ± 0.2 mg/dL/year, respectively, followed by a steep increase by which they attained diabetes. Until immediately before the diabetes transition, age- and sex-adjusted mean level of 2-hour PG was 149 ± 2.7 mg/dL, 34 ± 2.7 (30%) higher compared to nonprogressors, while that of 1-hour PG was 206 ± 4.1 mg/dL, 60 ± 4.3 mg/dL (41%) higher compared to nonprogressors. In conclusion, diabetes transition was preceded by a mild elevation of 2-hour PG for several years or more. The elevation in 1-hour PG was larger than that of 2-hour PG until immediately before the transition to diabetes. © 2017 Rie Oka et al.<br />Embargo Period 12 months 続きを見る
- URL:
- http://hdl.handle.net/2297/00049541
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