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Clinical and Pathological Significance of Autoantibodies to Erythropoietin Receptor in Type 2 Diabetic Patients With CKD
- フォーマット:
- 論文
- 責任表示:
- Hara, Akinori ; Furuichi, Kengo ; Koshino, Akihiko ; Yasuda, Haruka ; Tran, Trang Thi Thu ; Iwata, Yasunori ; Sakai, Norihiko ; Shimizu, Miho ; Kaneko, Shuichi ; Nakamura, Hiroyuki ; Wada, Takashi ; 原, 章規 ; 古市, 賢吾 ; 岩田, 恭宜 ; 坂井, 宣彦 ; 清水, 美保 ; 金子, 周一 ; 中村, 裕之 ; 和田, 隆志
- 言語:
- 英語
- 出版情報:
- Elsevier Inc, 2018-01-01
- 著者名:
- 掲載情報:
- Kidney International Reports
- ISSN:
- 2468-0249
- 巻:
- 3
- 通号:
- 1
- 開始ページ:
- 133
- 終了ページ:
- 141
- バージョン:
- author
- 概要:
- 金沢大学医薬保健研究域医学系<br />Introduction: We examined the impact of autoantibodies on the erythropoietin receptor (EPOR) in type 2 diabetic patients with chronic kidney disease (CKD). Methods: A total of 112 Japanese patients with type 2 diab … etes who had CKD were enrolled in this study and followed for a mean of 45 months. Sera from these patients were screened for anti-EPOR antibodies using enzyme-linked immunosorbent assays. Results: Anti-EPOR antibodies were detected in 26 patients (23%). Anti-EPOR antibodies were associated with low hemoglobin concentrations and decreased renal function. In patients with biopsy-proven diabetic nephropathy, anti-EPOR antibodies were associated with increased levels of interstitial inflammation. A decrease in renal function was observed more frequently in patients with antibodies than in those without antibodies, and the presence of the antibodies together with well-known clinical parameters, including proteinuria and low glomerular filtration rate, was a significant risk factor for end-stage renal disease. In human tubular epithelial HK-2 cells, IgG fractions containing anti-EPOR antibodies upregulated the expression of monocyte chemoattractant protein-1 mRNA under a high concentration of glucose. Conclusion: Anti-EPOR antibodies might be involved in the progression of renal lesions and in the impaired erythropoiesis in type 2 diabetic patients with CKD. Furthermore, the presence of anti-EPOR antibodies may be an additional predictor for end-stage renal disease in type 2 diabetes. © 2017 International Society of Nephrology<br />Embargo Period 12 months 続きを見る
- URL:
- http://hdl.handle.net/2297/00050598
類似資料:
金沢大学十全医学会, The Juzen Medical Society Kanazawa University | |
日本痛風・核酸代謝学会 = Japanese Society of Gout and Nucleic Acid Metabolism | |
Public Library of Science | |
Oxford University Press | |
Japanese Society of Nephrology (JSN) 日本腎臓学会 / Springer Verlag (Germany) |
金沢大学附属病院血液浄化療法部 |
金沢大学十全医学会, The Juzen Medical Society Kanazawa University |
金沢大学附属病院血液浄化療法部 |