抗癌剤および血管新生阻害剤による口腔扁平上皮癌の浸潤・転移抑制効果

フォーマット:

論文

責任表示:

川尻, 秀一 ; Kawashiri, Shuichi

言語:

日本語

出版情報:

金沢大学医薬保健研究域医学系, 2011-05-18

著者名:

• 川尻, 秀一
• Kawashiri, Shuichi

掲載情報:

平成22(2010)年度 科学研究費補助金 基盤研究(C) 研究成果報告書 = 2010 Fiscal Year Final Research Report

巻:

2008-2010

開始ページ:

6p.

バージョン:

author

概要:

口腔扁平上皮癌の臨床での浸潤および転移を忠実に再現できるマウス正所性移植モデルを用いて、抗癌剤と血管新生阻害剤の効果を検討した。癌細胞は高浸潤高転移性のヒトロ腔扁平上皮癌細胞株であるOSC-19細胞を使用し、ヌードマウスの口腔底もしくは舌に移植した。抗癌剤はシスプラチンを血管新生阻害薬はトラニラストを用いて、浸潤と転移の阻止効果を調べた。その結果、腫瘍の大きさ、浸潤様式のダウングレード、リンパ節転移にそれぞれ効果を認め、臨床的にも有意義であると考えられた。<br /&g … t;Using an orthotopic implantation mice model in which the invasion and metastasis of oral cancer can be reproduced, we investigated the inhibitory effects of anticancer agent and angiogenesis inhibitor on invasion and metastasis. A highly invasive and metastatic human oral squamous cell carcinoma cell line, OSC-19, was implanted into the tongue or oral floor of nude mice, and cisplatin or tranilast were administered to the mice after the implantation. The effects of each drug on cancer invasion and metastasiswere investigated. Tumor size and the ratio of proliferating cell nuclear antigen positive cells were significantly reduced. In the control group, the tumors showed grade 4C of mode of invasion, while in the groups treated with anticancer agent and angiogenesis inhibitor, grade 3 was observed, with an inhibitory effect on tumor invasion being observed. The rate of metastasis in the cervical lymph node was significantly decreased in the groups treated with the anticancer agent and angiogenesis inhibitor. The tumor stage progression in the metastatic lymph nodes was also inhibited. The use of anticancer agent and angiogenesis inhibitor considering these effects may be clinically very useful. 続きを見る

URL:

http://hdl.handle.net/2297/00050674