近赤外分光法による Ischemic Preconditioning 効果の診断

フォーマット:

論文

責任表示:

池田, 真浩 ; 永峰, 洋 ; 富田, 重之 ; 牛島, 輝明 ; 竹村, 博文 ; 榊原, 直樹 ; 川筋, 道雄 ; 渡辺, 洋宇 ; Ikeda, M. ; Nagamine, Hiroshi ; Tomita, Shigeyuki ; Ushijima, Teruaki ; Takemura, Hirofumi ; Sakakibara, Naoki ; Kawasuji, Michio ; Watanabe, Yoh

言語:

日本語

出版情報:

日本心臓血管外科学会 = The Japanese Society for Cardiovascular Surgery / 南江堂, 1998-12

著者名:

池田, 真浩

永峰, 洋

富田, 重之

牛島, 輝明

竹村, 博文

榊原, 直樹

川筋, 道雄

渡辺, 洋宇

Ikeda, M.

Nagamine, Hiroshi

Tomita, Shigeyuki

Ushijima, Teruaki

Takemura, Hirofumi

Sakakibara, Naoki

Kawasuji, Michio

Watanabe, Yoh

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掲載情報:

胸部外科 = 日本心臓血管外科学会雑誌 = The Japanese journal of thoracic surgery

ISSN:

0021-5252      

巻:

51

通号:

13

開始ページ:

1095

終了ページ:

1098

バージョン:

publisher

概要:

金沢大学医薬保健研究域医学系<br />Ischemic preconditioning (IP) protects the myocardium from subsequent sustained ischemic insults. Temporary occlusion of the coronary artery is indispensable for anastomosing the graft vessel during coronary artery … bypass operation without cardiopulmonary bypass. In the canine model of ischemia and reperfusion, we measured myocardial tissue oxygen saturation (SO2) continuously using near-infrared spectroscopy to determine the effect of IP on myocardial oxygen metabolism. Nine dogs underwent occlusion of the left descending coronary artery for three 5-minute periods, followed by three 5-minute periods of reperfusion. The dogs were then subjected to a 20-minutes periods of sustained coronary artery occlusion, followed by prolonged reperfusion. The myocardial SO2 was 82 +/- 2% at the baseline before coronary occlusion and was decreased to 74 +/- 2%, 76 +/- 2%, 77 +/- 3%, 77 +/- 3% at the first, second, third and sustained coronary occlusion, respectively. The increase in the minimum myocardial SO2 value at the second and third coronary occlusion suggested the effect of IP. Near-infrared spectroscopy is a useful method of continuously monitoring myocardial oxygenation and of evaluating the effect of IP during off-pump heart surgery. 続きを見る

URL:

http://hdl.handle.net/2297/00051008