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Effects of carvedilol pretreatment on mortality and inflammatory responses to septic shock induced by cecal ligation and puncture in rats

フォーマット:
論文
責任表示:
Yuki, Midori
言語:
英語
出版情報:
金沢大学十全医学会 — The Juzen Medical Society Kanazawa University, 2018-03
著者名:
Yuki, Midori  
掲載情報:
金沢大学十全医学会雑誌 = Journal of the Juzen Medical Society
ISSN:
0022-7226  CiNii Research  Webcat Plus  JAIRO
巻:
127
通号:
1
開始ページ:
10
終了ページ:
15
バージョン:
publisher
概要:
Purpose: Carvedilol, a nonselective beta-adrenoceptor and selective alpha 1-adrenoceptor blocker, has high efficacy and is widely used in hypertensive and/or cardiac failure patients. However, few studies have examined the effects of carvedilol on septic shock. The present study evaluated the effects of carvedilol pretreatment in cecal ligation and puncture (CLP)-induced septic shock in rats. Methods: Male Sprague Dawley rats (n = 90) were randomly assigned to one of the following three groups (n = 30 per group): control group (no medication), high-dose carvedilol group (10 mg/kg/day, orally administered for 5 days), and low-dose carvedilol group (2 mg/kg/day, orally administered for 5 days). Septic shock was induced by CLP, and the animals received no other therapies. Mortality was calculated for 5 days after CLP. Arterial blood gases and plasma cytokine concentrations were measured in 36 additional male rats 12 hr after CLP. Results: Mortality rates 5 days after CLP were 76.7%, 86.7%, and 86.7% in the control, high-dose, and low-dose groups, respectively; there were no significant differences among the three groups. Furthermore, observed decreases in base excess, increases in lactate concentrations, and increases in cytokine concentrations in the carvedilol-treated groups did not differ from those in the control group. Conclusions: The present findings indicate that orally administered carvedilol has no beneficial effects on mortality and inflammatory responses in CLP-induced septic shock in rats, suggesting that carvedilol may not contribute to recovery from septic shock. 続きを見る
URL:
http://hdl.handle.net/2297/00051111
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