Sitosterolemia, Hypercholesterolemia, and Coronary Artery Disease

Sitosterolemia, Hypercholesterolemia, and Coronary Artery Disease

フォーマット:

論文

責任表示:

Tada, Hayato ; Nohara, Atsushi ; Inazu, Akihiro ; Sakuma, Nagahiko ; Mabuchi, Hiroshi ; Kawashiri, Masa-aki ; 多田, 隼人 ; 野原, 淳 ; 稲津, 明広 ; 馬淵, 宏 ; 川尻, 剛照

言語:

英語

出版情報:

日本動脈硬化学会 = Japan Atherosclerosis Society, 2018

著者名:

掲載情報:

Journal of Atherosclerosis and Thrombosis

ISSN:

1340-3478

巻:

25

通号:

9

開始ページ:

783

終了ページ:

789

バージョン:

publisher

概要:

金沢大学附属病院循環器内科<br />Sitosterolemia is a rare inherited disease characterized by increased levels of plant sterols, such as sitosterol. The cause of this disease is ATP-binding cassette (ABC) subfamily G member 5 or member 8 (ABCG5 or A … BCG8, respectively) gene mutations. Recent advances in genetics have revealed that the prevalence of subjects with deleterious mutations in ABCG5 and/or ABCG8 genes could be more than 1 in ~200,000 individuals among the general population. Furthermore, accumulated evidence, including infantile cases exhibiting progression/regression of systemic xanthomas associated with LDL cholesterol levels, have shown that the elevation of LDL cholesterol seems to be the major cause of development of atherosclerosis and not the elevation of sitosterol. Regarding therapies, LDL apheresis, as well as proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, could be useful for sitosterolemia, in addition to ezetimibe and/or colestimide. In this study, we provide the current understanding and future perspectives of sitosterolemia, which is currently considered an extremely rare disorder but is expected to be much more prevalent in clinical settings.<br />This article distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License. 続きを見る

URL:

http://hdl.handle.net/2297/00053008

タイトル・著者・出版者が同じ資料

詳細

主題:	ABCG5; ABCG8; Familial hypercholesterolemia; Sitosterolemia
受理日:	2018

類似資料:

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1 論文 A Rare Coincidence of Sitosterolemia and Familial Mediterranean Fever Identified by Whole Exome Sequencing. Tada, Hayato, Kawashiri, Masa-aki, Okada, Hirofumi, Endo, Saori, Toyoshima, Yuka, Konno, Tetsuo, Nohara, Atsushi, Inazu, … Japan Atherosclerosis Society = 日本動脈硬化学会	7 論文 Marked aortic valve stenosis progression after receiving long-term aggressive cholesterol-lowering therapy using low-density lipoprotein apheresis in a patient … Tsuchida, Masayuki, Kawashiri, Masa-aki, Tada, Hayato, Takata, Mutsuko, Nohara, Atsushi, Ino, Hidekazu, Inazu, Akihiro, … Japanese Circulation Society = 日本循環器学会
2 論文 Post-prandial Remnant Lipoprotein Metabolism in Sitosterolemia Tada, Hayato, Nomura, Akihiro, Nohara, Atsushi, Inazu, Akihiro, Mabuchi, Hiroshi, YAMAGISHI, Masakazu, Kawashiri, … 日本動脈硬化学会 = Japan Atherosclerosis Society	8 論文 Clinical Perspectives of Genetic Analyses on Dyslipidemia and Coronary Artery Disease Tada, Hayato, Kawashiri, Masa-aki, Yamagishi, Masakazu, 多田, 隼人, 川尻, 剛照, 山岸, 正和日本動脈硬化学会 = Japan Atherosclerosis Society
3 論文 Oral Fat Tolerance Test for Sitosterolemia and Familial Hypercholesterolemia: A Study Protocol Nomura, Akihiro, Tada, Hayato, Nohara, Atsushi, Kawashiri, Masa-aki, Yamagishi, Masakazu, 野村, 章洋, 多田, … 日本動脈硬化学会 = Japan Atherosclerosis Society	9 論文 Cholesterol-years score is associated with development of senile degenerative aortic stenosis in heterozygous familial hypercholesterolemia. Nozue, Tsuyoshi, Kawashiri, Masa-aki, Higashikata, Toshinori, Nohara, Atsushi, Inazu, Akihiro, Kobayashi, Junji, … Japan Atherosclerosis Society = 日本動脈硬化学会
4 論文 Autosomal Recessive Hypercholesterolemia: A Mild Phenotype of Familial Hypercholesterolemia: Insight from the Kinetic Study using Stable Isotope and Animal … Tada, Hayato, Kawashiri, Masa-aki, Nohara, Atsushi, Inazu, Akihiro, Kobayashi, Junji, Mabuchi, Hiroshi, Yamagishi, … Japan Atherosclerosis Society = 日本動脈硬化学会	10 論文 Changes in lipoprotein lipase and endothelial lipase mass in familial hypercholesterolemia during three-drug lipid-lowering combination therapy. Tada, Hayato, Kobayashi, Junji, Kawashiri, Masa-aki, Miyashita, Kazuya, Nohara, Atsushi, Inazu, Akihiro, Nakajima, … BioMed Central
5 論文 Marked transient hypercholesterolemia caused by low-dose mitotane as adjuvant chemotherapy for adrenocortical carcinoma Tada, Hayato, Nohara, Atsushi, Kawashiri, Masa-aki, Inazu, Akihiro, Mabuchi, Hiroshi, Yamagishi, Masakazu, 多田, … Japan Atherosclerosis Society = 日本動脈硬化学会	11 論文 A novel type of familial hypercholesterolemia: Double heterozygous mutations in LDL receptor and LDL receptor adaptor protein 1 gene Tada, Hayato, Kawashiri, Masa-aki, Ohtani, Rumiko, Noguchi, Tohru, Nakanishi, Chiaki, Konno, Tetsuo, Hayashia, Kenshi, … Elsevier Science Ireland
6 論文 Lipoprotein(a) in Familial Hypercholesterolemia With Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Gain-of-Function Mutations. Tada, Hayato, Kawashiri, Masa-aki, Yoshida, Taiji, Teramoto, Ryota, Nohara, Atsushi, Konno, Tetsuo, Inazu, Akihiro, … Japanese Circulation Society = 日本循環器学会	12 論文 A novel type of familial hypercholesterolemia: Double heterozygous mutations in LDL receptor and LDL receptor adaptor protein 1 gene Tada, Hayato, Kawashiri, Masa-aki, Ohtani, Rumiko, Noguchi, Tohru, Nakanishi, Chiaki, Konno, Tetsuo, Hayashi, Kenshi, … Elsevier