Regulation of Gut Microbiota and Metabolic Endotoxemia with Dietary Factors

フォーマット:

論文

責任表示:

Fuke, Nobuo ; Nagata, Naoto ; Suganuma, Hiroyuki ; Ota, Tsuguhito ; 長田, 直人 ; 太田, 嗣人

言語:

英語

出版情報:

Multidisciplinary Digital Publishing Institute (MDPI), 2019-09-23

著者名:

Fuke, Nobuo

Nagata, Naoto

Suganuma, Hiroyuki

Ota, Tsuguhito

長田, 直人

太田, 嗣人

続きを見る

掲載情報:

Nutrients

ISSN:

2072-6643      

巻:

11

通号:

10

開始ページ:

38p.

バージョン:

publisher

概要:

金沢大学医学系細胞分子機能学<br />Metabolic endotoxemia is a condition in which blood lipopolysaccharide (LPS) levels are elevated, regardless of the presence of obvious infection. It has been suggested to lead to chronic inflammation-related disea … ses such as obesity, type 2 diabetes mellitus, non-alcoholic fatty liver disease (NAFLD), pancreatitis, amyotrophic lateral sclerosis, and Alzheimer's disease. In addition, it has attracted attention as a target for the prevention and treatment of these chronic diseases. As metabolic endotoxemia was first reported in mice that were fed a high-fat diet, research regarding its relationship with diets has been actively conducted in humans and animals. In this review, we summarize the relationship between fat intake and induction of metabolic endotoxemia, focusing on gut dysbiosis and the influx, kinetics, and metabolism of LPS. We also summarize the recent findings about dietary factors that attenuate metabolic endotoxemia, focusing on the regulation of gut microbiota. We hope that in the future, control of metabolic endotoxemia using dietary factors will help maintain human health. 続きを見る

URL:

http://hdl.handle.net/2297/00055660