Primary localized malignant biphasic mesothelioma of the liver in a patient with asbestosis

フォーマット:

論文

責任表示:

Sasaki, Motoko ; Araki, Ichiro ; Yasui, Toshiaki ; Kinoshita, Masaru ; Itatsu, Keita ; Nojima, Takayuki ; Nakanuma, Yasuni ; 佐々木, 素子 ; 野島, 孝之 ; 中沼, 安二

言語:

英語

出版情報:

Baishideng Publishing Group Co, 2009

著者名:

Sasaki, Motoko

Araki, Ichiro

Yasui, Toshiaki

Kinoshita, Masaru

Itatsu, Keita

Nojima, Takayuki

Nakanuma, Yasuni

佐々木, 素子

野島, 孝之

中沼, 安二

続きを見る

掲載情報:

World Journal of Gastroenterology

ISSN:

1007-9327      

巻:

15

通号:

5

開始ページ:

615

終了ページ:

621

バージョン:

publisher

概要:

金沢大学医薬保健研究域医学系<br />We report a case of primary localized malignant biphasic mesothelioma of the liver in a 66-year-old man associated with asbestosis. The tumor was detected as a hepatic nodule, 4 cm in diameter, in the right lobe (S … 8 segment) on CT scan. Histopathological examination demonstrated an intrahepatic tumor with central necrosis consisting of a papillary epithelioid pattern on the surface of the liver, microcystic (microglandular or adenomatoid) pattern mainly in the subcapsular area and sarcomatoid pattern intermingled with microcystic pattern in the major part of the hepatic nodular tumor. Tumor cells, especially of epithelioid type, showed distinct immunoreactivity for mesothelial markers (WT-1, calretinin, D2-40, CK5/6, mesothelin, thrombomodulin) and no immunoreactivity for epithelial (adenocarcinoma) markers (CEA, CD15, BerEP4, BG8, MOC31). P53 immunoreactivity was detected focally in papillary epithelioid tumor cells and extensively in microcystic and sarcomatoid components, suggesting that the papillary epithelioid mesothelioma arose on the surface of the liver, and tumor cells showing microcystic and sarcomatoid patterns invaded and grew into the liver. To date, this is the first case of primary localized malignant biphasic mesothelioma of the liver, since all three primary hepatic mesotheliomas reported so far were epithelioid type. © 2009 The WJG Press and Baishideng. All rights reserved. 続きを見る

URL:

http://hdl.handle.net/2297/00061734