Gas6 derived from cancer-associated fibroblasts promotes migration of Axl-expressing lung cancer cells during chemotherapy

Gas6 derived from cancer-associated fibroblasts promotes migration of Axl-expressing lung cancer cells during chemotherapy

フォーマット:

論文

責任表示:

Ryu Kanzaki, ; Naito, Hisamichi ; Kise, Kazuyoshi ; Takara, Kazuhiro ; Eino, Daisuke ; Minami, Masato ; Shintani, Yasushi ; Funaki, Soichiro ; Kawamura, Tomohiro ; Kimura, Toru ; Okumura, Meinoshin ; Takakura, Nobuyuki ; 内藤, 尚道 ; 高倉, 伸幸

言語:

英語

出版情報:

Nature Research / Nature Publishing Group, 2017-09-06

著者名:

掲載情報:

Scientific Reports

ISSN:

2045-2322

巻:

7

通号:

1

開始ページ:

10613

バージョン:

publisher

概要:

金沢大学医薬保健研究域医学系<br />Alterations to the tumor stromal microenvironment induced by chemotherapy could influence the behavior of cancer cells. In the tumor stromal microenvironment, cancer-associated fibroblasts (CAFs) play an important … role. Because the receptor tyrosine kinase Axl and its ligand Gas6 could be involved in promoting non-small cell lung cancer (NSCLC), we investigated the role of Gas6 secreted by CAFs during chemotherapy in NSCLC. In a murine model, we found that Gas6 expression by CAFs was upregulated following cisplatin treatment. Gas6 expression might be influenced by intratumoral hypoperfusion during chemotherapy, and it increased after serum starvation in a human lung CAF line, LCAFhTERT. Gas6 is associated with LCAFhTERT cell growth. Recombinant Gas6 promoted H1299 migration, and conditioned medium (CM) from LCAFhTERT cells activated Axl in H1299 cells and promoted migration. Silencing Gas6 in LCAFhTERT reduced the Axl activation and H1299 cell migration induced by CM from LCAFhTERT. In clinical samples, stromal Gas6 expression increased after chemotherapy. Five-year disease-free survival rates for patients with tumor Axl- and stromal Gas6-positive tumors (n = 37) was significantly worse than for the double negative group (n = 12) (21.9% vs 51.3%, p = 0.04). Based on these findings, it is presumed that Gas6 derived from CAFs promotes migration of Axl-expressing lung cancer cells during chemotherapy and is involved in poor clinical outcome. © 2017 The Author(s). 続きを見る

URL:

http://hdl.handle.net/2297/00062988

タイトル・著者・出版者が同じ資料

詳細

受理日:	2017-09-06

類似資料:

1

2

3

4

5

6

7

8

9

10

11

12

1 論文 Changes in blood vessel maturation in the fibrous cap of the tumor rim Naito, Hisamichi, Takara, Kazuhiro, Wakabayashi, Taku, Kawahara, Hiroki, Kidoya, Hiroyasu, Takakura, Nobuyuki, 内藤, … Japanese Cancer Association 日本癌学会 / wiley	7 論文 Ligand-independent Tie2 dimers mediate kinase activity stimulated by high dose angiopoietin-1 Yamakawa, Daishi, Kidoya, Hiroyasu, Sakimoto, Susumu, Jia, Weizhen, Naito, Hisamichi, Takakura, Nobuyuki, 内藤, 尚道, 高倉, 伸幸 American Society for Biochemistry and Molecular Biology / Elsevier
2 論文 Tumor Endothelial Cell-Specific Drug Delivery System Using Apelin-Conjugated Liposomes Kawahara, Hiroki, Naito, Hisamichi, Takara, Kazuhiro, Wakabayashi, Taku, Kidoya, Hiroyasu, Takakura, Nobuyuki, 内藤, … Public Library of Science	8 論文 Fluorescence and bioluminescence imaging of angiogenesis in Flk1-Nano-lantern transgenic mice Matsushita, Jun, Inagaki, Shigenori, Nishie, Tomomi, Sakasai, Tomoki, Tanaka, Junko, Watanabe, Chisato, Mizutani, … Nature Research / Nature Publishing Group
3 論文 Regulation of SLD5 gene expression by miR-370 during acute growth of cancer cells Yamane, Keitaro, Naito, Hisamichi, Wakabayashi, Taku, Yoshida, Hironori, Muramatsu, Fumitaka, Iba, Tomohiro, Kidoya, … Nature Research / Nature Publishing Group	9 論文 Indispensable role of Galectin-3 in promoting quiescence of hematopoietic stem cells Jia, Weizhen, Kong, Lingyu, Kidoya, Hiroyasu, Naito, Hisamichi, Muramatsu, Fumitaka, Hayashida, Yumiko, Hsieh, Han-Yun, … Nature Research / Nature Publishing Group
4 論文 Isolation of tissue-resident endothelial stem cells and their use in regenerative medicine Iba, Tomohiro, Naito, Hisamichi, Shimizu, Shota, Rahmawati, Fitriana Nur, Wakabayashi, Taku, Takakura, Nobuyuki, 内藤, … BioMed Central Ltd.	10 論文 An Angiogenic Role for Adrenomedullin in Choroidal Neovascularization Sakimoto, Susumu, Kidoya, Hiroyasu, Kamei, Motohiro, Naito, Hisamichi, Yamakawa, Daishi, Sakaguchi, Hirokazu, … Public Library of Science
5 論文 Identification of vascular endothelial side population cells in the choroidal vessels and their potential role in age- related macular degeneration Wakabayashi, Taku, Naito, Hisamichi, Takara, Kazuhiro, Kidoya, Hiroyasu, Sakimoto, Susumu, Oshima, Yusuke, Nishida , … Association for Research in Vision and Ophthalmology	11 論文 A role for endothelial cells in promoting the maturation of astrocytes through the apelin/APJ system in mice Sakimoto, Susumu, Kidoya, Hiroyasu, Naito, Hisamichi, Kamei, Motohiro, Sakaguchi, Hirokazu, Goda, Nobuhito, Fukamizu, … The Company of Biologists [Society
6 論文 Soluble HLA-associated peptide from PSF1 has a cancer vaccine potency Yoshida, Mari, Ishioka, Yukichi, Ozawa, Takamasa, Okuyama, Hirohisa, Iguchi, Motofumi, Ota, Takeshi, Ito, Takaomi, … Nature Research / Nature Publishing Group	12 論文 Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis Kidoya, Hiroyasu, Muramatsu, Fumitaka, Shimamura, Teppei, Jia, Weizhen, Satoh, Takashi, Hayashida, Yumiko, Naito, … Nature Research / Nature Publishing Group