Impact of MDM2 single nucleotide polymorphism on tumor onset in head and neck squamous cell carcinoma

フォーマット:

論文

責任表示:

Nakashima, Masashi ; Kondo, Satoru ; Shimizu, Yoshinori ; Wakisaka, Naohiro ; Murono, Shigeyuki ; Furukawa, Mitsuru ; Yoshizaki, Tomokazu

言語:

英語

出版情報:

Taylor & Francis, 2008-07-01

著者名:

Nakashima, Masashi

Kondo, Satoru

Shimizu, Yoshinori

Wakisaka, Naohiro

Murono, Shigeyuki

Furukawa, Mitsuru

Yoshizaki, Tomokazu

続きを見る

掲載情報:

Acta Oto-Laryngologica

ISSN:

0001-6489      

巻:

128

通号:

7

開始ページ:

808

終了ページ:

813

バージョン:

author

概要:

金沢大学附属病院耳鼻咽喉科・頭頸部外科<br />Conclusions. The GG genotype of MDM2 SNP309 is associated with an earlier onset of head and neck squamous cell carcinoma (HNSCC) in the Japanese population. SNP309 may be a key factor in the tumorigenesis of H … NSCC as well as other hereditary or sporadic tumors. Objective. This study was designed to evaluate the association between the single nucleotide polymorphism (SNP) 309 in the MDM2 gene with HNSCC. An MDM2 protein down-regulates the p53 pathway. Recently, an important SNP was discovered in the MDM2 promoter region, which could affect the tumorigenesis of HNSCC by attenuation of the p53 pathway. Patients and methods. Patients with 103 HNSCCs were genotyped using direct sequencing and real-time PCR. The relationship between the SNP309 genotypes and the clinicopathological features was statistically analyzed. Results. The number of patients genotyped to TT, TG, and GG was 29 (28%), 46 (44.7%), and 28 (27.2%), respectively. The average age at tumor onset was 65.6 years for TT, 62.9 years for TG, and 56.7 years for GG. The patients with the GG genotype had a significantly earlier tumor onset in comparison to those with the TT genotype (p=0.032). © 2008 Taylor & Francis.全文公開200907 続きを見る

URL:

http://hdl.handle.net/2297/10937