Increased oxidative stress precedes the onset of high-fat diet-induced insulin resistance and obesity

Increased oxidative stress precedes the onset of high-fat diet-induced insulin resistance and obesity

フォーマット:

論文

責任表示:

Matsuzawa-Nagata, Naoto ; Takamura, Toshinari ; Ando, Hitoshi ; Nakamura, Seiji ; Kurita, Seiichiro ; Misu, Hirofumi ; Ota, Tsuguhito ; Yokoyama, Masayoshi ; Honda, Masao ; Miyamoto, Ken-ichi ; Kaneko, Shuichi

言語:

英語

出版情報:

Elsevier, 2008-08-01

著者名:

Matsuzawa-Nagata, Naoto

掲載情報:

Metabolism: Clinical and Experimental

ISSN:

0026-0495

巻:

57

通号:

8

開始ページ:

1071

終了ページ:

1077

バージョン:

author

概要:

金沢大学医薬保健研究域医学系<br />Insulin resistance is a key pathophysiological feature of metabolic syndrome. However, the initial events triggering the development of insulin resistance and its causal relations with dysregulation of glucose and … fatty acids metabolism remain unclear. We investigated biological pathways that have the potential to induce insulin resistance in mice fed a high-fat diet (HFD). We demonstrate that the pathways for reactive oxygen species (ROS) production and oxidative stress are coordinately up-regulated in both the liver and adipose tissue of mice fed an HFD before the onset of insulin resistance through discrete mechanism. In the liver, an HFD up-regulated genes involved in sterol regulatory element binding protein 1c-related fatty acid synthesis and peroxisome proliferator-activated receptor α-related fatty acid oxidation. In the adipose tissue, however, the HFD down-regulated genes involved in fatty acid synthesis and up-regulated nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. Furthermore, increased ROS production preceded the elevation of tumor necrosis factor-α and free fatty acids in the plasma and liver. The ROS may be an initial key event triggering HFD-induced insulin resistance. © 2008 Elsevier Inc. All rights reserved. 続きを見る

URL:

http://hdl.handle.net/2297/11570

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詳細

受理日:	2008-08-01

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