Combined pure red cell aplasia and autoimmune hemolytic anemia in systemic lupus erythematosus with anti-erythropoietin autoantibodies

Combined pure red cell aplasia and autoimmune hemolytic anemia in systemic lupus erythematosus with anti-erythropoietin autoantibodies

フォーマット:

論文

責任表示:

Hara, Akinori ; Wada, Takashi ; Kitajima, Shinji ; Toyama, Tadashi ; Okumura, Toshiya ; Kitagawa, Kiyoki ; Iwata, Yasunori ; Sakai, Norihiko ; Furuichi, Kengo ; Higuchi, Masato ; Kaneko, Shuichi

言語:

英語

出版情報:

John Wiley & Sons, 2008-09-01

著者名:

掲載情報:

American Journal of Hematology

ISSN:

0361-8609

巻:

83

通号:

9

開始ページ:

750

終了ページ:

752

バージョン:

author

概要:

金沢大学医薬保健研究域医学系<br />A 42-year-old woman with systemic lupus erythematosus was admitted to our hospital because of severe anemia. Her bone marrow was almost normocellular and erythroblasts were nearly absent. Laboratory data showed ele … vated levels of lactate dehydrogenase and positive findings on Coombs' tests. On the basis of these findings, her anemia was diagnosed as the overlap of pure red cell aplasia with autoimmune hemolytic anemia. Radioimmunoprecipitation assay revealed that her serum was positive for anti-erythropoietin antibodies before therapy. Furthermore, the autoantibodies inhibited proliferation of an erythropoietin-dependent cell line in a dose-dependent manner. Immunosuppressive treatment improved the anemia accompanied with disappearance of the autoantibodies. © 2008 Wiley-Liss, Inc. 続きを見る

URL:

http://hdl.handle.net/2297/11836

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詳細

受理日:	2008-09-01

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