Blank Cover Image

Sphingosine-1-phosphate signaling and biological activities in the cardiovascular system

フォーマット:
論文
責任表示:
Takuwa, Yoh ; Okamoto, Yasuo ; Yoshioka, Kazuaki ; Takuwa, Noriko
言語:
英語
出版情報:
Elsevier, 2008-09-01
著者名:
掲載情報:
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
ISSN:
1388-1981  CiNii Articles  Webcat Plus  JAIRO
巻:
1781
通号:
9
開始ページ:
483
終了ページ:
488
バージョン:
author
概要:
金沢大学医薬保健研究域医学系<br />The plasma lysophospholipid mediator sphingosine-1-phosphate (S1P) is produced exclusively by sphingosine kinase (SPHK) 1 and SPHK2 in vivo, and plays diverse biological and pathophysiological roles by acting large ly through three members of the G protein-coupled S1P receptors, S1P1, S1P2 and S1P3. S1P1 expressed on endothelial cells mediates embryonic vascular maturation and maintains vascular integrity by contributing to eNOS activation, inhibiting vascular permeability and inducing endothelial cell chemotaxis via Gi-coupled mechanisms. By contrast, S1P2, is expressed in high levels on vascular smooth muscle cells (VSMCs) and certain types of tumor cells, inhibiting Rac and cell migration via a G12/13-and Rho-dependent mechanism. In rat neointimal VSMCs, S1P1 is upregulated to mediate local production of platelet-derived growth factor, which is a key player in vascular remodeling. S1P3 expressed on endothelial cells also mediates chemotaxis toward S1P and vasorelaxation via NO production in certain vascular bed, playing protective roles for vascular integrity. S1P3 expressed on VSMCs and cardiac sinoatrial node cells mediates vasopressor and negative chronotropic effect, respectively. In addition, S1P3, together with S1P2 and SPHK1, is suggested to play a protective role against acute myocardial ischemia. However, our recent work indicates that overexpressed SPHK1 is involved in cardiomyocyte degeneration and fibrosis in vivo, in part through S1P activation of the S1P3 signaling. We also demonstrated that exogenously administered S1P accelerates neovascularization and blood flow recovery in ischemic limbs, suggesting its usefulness for angiogenic therapy. These results provide evidence for S1P receptor subtype-specific pharmacological intervention as a novel therapeutic approach to cardiovascular diseases and cancer. © 2008 Elsevier B.V. All rights reserved. 続きを見る
URL:
http://hdl.handle.net/2297/11867

類似資料:

1
 
2
 
3
 
4
 
5
 
6
 
7
 
8
 
9
 
10
 
11
 
12
 

Takuwa, Yoh, Okamoto, Yasuo, Yoshioka, Kazuaki, Takuwa, Noriko

Elsevier

Takashima, Shinichiro, Sugimoto, Naotoshi, Takuwa, Noriko, Okamoto, Yasuo, Yoshioka, Kazuaki, Takamura, Masayuki, &hellip;

Elsevier

Takuwa, Yoh, Okamoto, Yasuo, Yoshioka, Kazuaki, Takuwa, Noriko

International Union of Biochemistry and Molecular Biology, Inc / Wiley-Blackwell

Takuwa, Yoh, Sugimoto, Naotoshi, Takuwa, Noriko, Igarashi, Yasuyuki

Springer-Verlag

Takuwaa, Yoh, Okamoto, Yasuo, Yoshioka, Kazuaki, Takuwa, Noriko

International Union of Biochemistry and Molecular Biology, Inc. / Wiley-Blackwell

Cui, Hong, Okamoto, Yasuo, Yoshioka, Kazuaki, Du, Wa, Takuwa, Noriko, Zhang, Wei, Asano, Masahide, Shibamoto, &hellip;

Elsevier

Qia, Xun, Okamoto, Yasuo, Murakawa, Tomomi, Wang, Fei, Oyama, Osamu, Ohkawa, Ryunosuke, Yoshioka, Kazuaki, Du, Wa, &hellip;

Elsevier BV

Du, Wa, Takuwa, Noriko, Yoshioka, Kazuaki, Okamoto, Yasuo, Gonda, Koichi, Sugihara, Kazushi, Fukamizu, Akiyoshi, Asano, &hellip;

American Association for Cancer Research

Takuwa, Yoh, Ikeda, Hitoshi, Okamoto, Yasuo, Takuwa, Noriko, Yoshioka, Kazuaki

Elsevier

Wang, Fei, Okamoto, Yasuo, Inoki, Isao, Yoshioka, Kazuaki, Du, Wa, Qi, Xun, Takuwa, Noriko, Gonda, Koichi, Yamamoto, &hellip;

American Society for Clinical Investigation

Cui, Hong, Okamoto, Yasuo, Yoshioka, Kazuaki, Du, Wa, Takuwa, Noriko, Zhang, Wei, Asano, Masahide, Shibamoto, &hellip;

Elsevier

Zhao, Juanjuan, Okamoto, Yasuo, Asano, Yuya, Ishimaru, Kazuhiro, Aki, Sho, Yoshioka, Kazuaki, Takuwa, Noriko, Wada, &hellip;

Public Library of Science