Ablation of the scaffold protein JLP causes reduced fertility in male mice

Ablation of the scaffold protein JLP causes reduced fertility in male mice

フォーマット:

論文

責任表示:

Iwanaga, Asuka ; Wang, Guangmin ; Gantulga, Davaakhuu ; Sato, Tokiharu ; Baljinnyam, Tuvshintugs ; Shimizu, Keiko ; Takumi, Ken ; Hayashi, Motoharu ; Akashi, Takuya ; Fuse, Hideki ; Sugihara, Kazushi ; Asano, Masahide ; Yoshioka, Katsuji

言語:

英語

出版情報:

Springer Science+Business Media B.V., 2008-12-01

著者名:

Baljinnyam, Tuvshintugs

掲載情報:

Transgenic Research

ISSN:

0962-8819

巻:

17

通号:

6

開始ページ:

1045

終了ページ:

1058

バージョン:

author

概要:

金沢大学がん研究所がん分子細胞制御<br />The specific and efficient activation of mitogen-activated protein kinase (MAPK) signaling modules is mediated, at least in part, by scaffold proteins. c-Jun NH2-terminal kinase (JNK)-associated leucine zipper p … rotein (JLP) was identified as a scaffold protein for JNK and p38 MAPK signaling modules. JLP is expressed nearly ubiquitously and is involved in intracellular signaling pathways, such as the Gα13 and Cdo-mediated pathway, in vitro. To date, however, JLP expression has not been analyzed in detail, nor are its physiological functions well understood. Here we investigated the expression of JLP in the mouse testis during development. Of the tissues examined, JLP was strongest in the testis, with the most intense staining in the elongated spermatids. Since the anti-JLP antibody used in this study can recognize both JLP and sperm-associated antigen 9 (SPAG9), a splice variant of JLP that has been studied extensively in primates, we also examined its expression in macaque testis samples. Our results indicated that in mouse and primate testis, the isoform expressed at the highest level was JLP, not SPAG9. We also investigated the function of JLP by disrupting the Jlp gene in mice, and found that the male homozygotes were subfertile. Taken together, these observations may suggest that JLP plays an important role in testis during development, especially in the production of functionally normal spermatozoa. © 2008 Springer Science+Business Media B.V. 続きを見る

URL:

http://hdl.handle.net/2297/12393

タイトル・著者・出版者が同じ資料

詳細

主題:	JLP; Knockout mouse; MAP kinase; SPAG9; Scaffold protein; Signal transduction
受理日:	2008-12-01

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1 論文 The scaffold protein JSAP1 regulates proliferation and differentiation of cerebellar granule cell precursors by modulating JNK signaling Sato, Tokiharu, Torashima, Takashi, Sugihara, Kazushi, Hirai, Hirokazu, Asano, Masahide, Yoshioka, Katsuji Elsevier	7 論文 The scaffold protein JLP plays a key role in regulating ultraviolet B-induced apoptosis in mice Enkhtuya, Radnaa, Sato, Tokiharu, Wakasugi, Mitsuo, Tuvshintugs, Baljinnyam, Miyata, Hirofumi, Sakurai, Takeshi, … Wiley
2 論文 Ablation of the scaffold protein JLP causes reduced fertility in male mice Iwanaga, A., Wang, Guang, Gantulga, D., Sato, Tokiharu, Baljinnyam, T., Shimizu, K., Takumi, K., Hayashi, M., Akashi, … 金沢大学がん研究所 = Kanazawa University Cancer Research Institute	8 論文 JSAP1 and JLP are required for ARF6 localization to the midbody in cytokinesis Tuvshintugs, Baljinnyam, Sato, Tokiharu, Enkhtuya, Radnaa, Yamashita, Katsumi, Yoshioka, Katsuji Blackwell Publishing
3 論文 The Scaffold Protein c-Jun NH2-Terminal Kinase-associated Leucine Zipper Protein Regulates Cell Migration through Interaction with the G Protein G13 Gantulga, Davaakhuu, Tuvshintugs, Baljinnyam, Endo, Yoshio, Takino, Takahisa, Sato, Hiroshi, Murakami, Seishi, Yoshioka, … 日本生化学会 = Japanese Biochemical Society	9 論文 Scaffold proteins in mammalian MAP kinase cascades Yoshioka, Katsuji 日本生化学会 = Japanese Biochemical Society
4 論文 Regulation of N-cadherin-based cell–cell interaction by JSAP1 Bayarsaikhan, Munkhuu, Takino, Takahisa, Gantulga, Davaakhuu, Yoshioka, Katsuji, Sato, Hiroshi Elsevier	10 論文 The scaffold protein c-Jun NH2-terminal kinase-associated leucine zipper protein regulates cell migration through interaction wity the G protein Gα13 Gantulga, D., Tuvshintugs, Baljinnyam, Endo, Yoshio, Takino, Takahisa, Sato, H., Murakami, S., Yoshioka, Katsuji 金沢大学がん研究所 = Kanazawa University Cancer Research Institute
5 論文 JNKシグナル伝達経路における足場タンパク質の同定とその機能解析善岡, 克次, Yoshioka, Katsuji 金沢大学がん進展制御研究所	11 論文 The scaffold protein JSAP1 regulates proliferation of cerebellar granule cell precursors by modulation JNK signaling Sato, Tokiharu, Torashima, T., Sugihara, K., Hirai, H., Asano, M., Yoshioka, Katsuji 金沢大学がん研究所 = Kanazawa University Cancer Research Institute
6 論文 Neural-specific ablation of the scaffold protein JSAP1 in mice causes neonatal death Iwanaga, A., Sato, Tokiharu, Sugihara, K., Hirano, A., Takakura, N., Okamoto, H., Asano, M., Yoshioka, Katsuji 金沢大学がん研究所 = Kanazawa University Cancer Research Institute	12 論文 Impairment of cardiomyogenesis in embryonic stem cells lacking scaffold protein JSAP Sato, T., Hidaka, K., Iwanaga, A., Ito, M., Asano, M., Nakabeppu, Y., Morisaki, T., Yoshioka, Katsuji 金沢大学がん研究所