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Hypergravity induces expression of cyclooxygenase-2 in the heart vessels
- フォーマット:
- 論文
- 責任表示:
- Oshima, Masanobu ; Oshima, Hiroko ; Taketo, Makoto Mark
- 言語:
- 英語
- 出版情報:
- Elsevier, 2005-05-01
- 著者名:
- 掲載情報:
- Biochemical and biophysical research communications
- ISSN:
- 0006-291x
- 巻:
- 330
- 通号:
- 3
- 開始ページ:
- 928
- 終了ページ:
- 933
- バージョン:
- author
- 概要:
- 金沢大学がん研究所<br />Cyclooxygenase-2 (COX-2), a rate-limiting enzyme for prostaglandin biosynthesis, is induced by various stimuli including mechanical stress and plays important roles in pathophysiological conditions. For example, gravita … tional stress has been shown to induce expression of COX-2 in bone tissues, which is essential for bone homeostasis. To investigate whether COX-2 is induced by gravitational loading in other tissues than bone, we exposed mice to hypergravity at 2G and 3G for 4 h. We demonstrate here that COX-2 is induced in the mouse heart vessels by hypergravity. Moreover, hypoxia-inducible factor (HIF)-1α and its downstream genes such as inducible nitric oxide synthase, vascular endothelial growth factor, and heme oxygenase-1 were induced in the heart simultaneously, while none of these genes were induced in the COX-2(−/−) mouse heart. Therefore, COX-2 induced in the heart helps protect the heart function against hypoxia under hypergravity condition through HIF-1α induction. 続きを見る
- URL:
- http://hdl.handle.net/2297/1651
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