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Hypergravity induces expression of cyclooxygenase-2 in the heart vessels

フォーマット:
論文
責任表示:
Oshima, Masanobu ; Oshima, Hiroko ; Taketo, Makoto Mark
言語:
英語
出版情報:
Elsevier, 2005-05-01
著者名:
掲載情報:
Biochemical and biophysical research communications
ISSN:
0006-291x  CiNii Research  Webcat Plus  JAIRO
巻:
330
通号:
3
開始ページ:
928
終了ページ:
933
バージョン:
author
概要:
金沢大学がん研究所<br />Cyclooxygenase-2 (COX-2), a rate-limiting enzyme for prostaglandin biosynthesis, is induced by various stimuli including mechanical stress and plays important roles in pathophysiological conditions. For example, gravita tional stress has been shown to induce expression of COX-2 in bone tissues, which is essential for bone homeostasis. To investigate whether COX-2 is induced by gravitational loading in other tissues than bone, we exposed mice to hypergravity at 2G and 3G for 4 h. We demonstrate here that COX-2 is induced in the mouse heart vessels by hypergravity. Moreover, hypoxia-inducible factor (HIF)-1α and its downstream genes such as inducible nitric oxide synthase, vascular endothelial growth factor, and heme oxygenase-1 were induced in the heart simultaneously, while none of these genes were induced in the COX-2(−/−) mouse heart. Therefore, COX-2 induced in the heart helps protect the heart function against hypoxia under hypergravity condition through HIF-1α induction. 続きを見る
URL:
http://hdl.handle.net/2297/1651
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