Synthetic philosophy: A study directed toward creation of an ideal synthetic method and its application for preventing global warming by combating desertification

フォーマット:

論文

責任表示:

Somei, Masanori

言語:

英語

出版情報:

Japan Institute of Heterocyclic Chemistry = 日本複素環化学研究所, 2008-05-01

著者名:

Somei, Masanori  

掲載情報:

Heterocycles

ISSN:

0385-5414      

巻:

75

通号:

5

開始ページ:

1021

終了ページ:

1053

バージョン:

author

概要:

金沢大学医薬保健研究域薬学系<br />金沢大学名誉教授<br />This review reports how the author has been realizing his synthetic philosophy and five dreams as his life work. The philosophy consists of such three elements as originality rate, intellectual … property factor, and application potential factor. On the basis of these elements, an ideal and an efficient synthesis are defined. In the study for the total synthesis of ergot alkaloids, the first concrete example of an approximately ideal synthesis was demonstrated. Further examples are shown relying on the chemistry of 1-hydroxyindoles. A lot of intellectual properties created by the author are successfully condensed to provide promising lead compounds meeting for the respective dreams of developing five drugs 1) for making desert green and food increase in production, 2) for cardiovascular system disease, 3) for dementia, 4) for lifestyle-related disease (osteoporosis, etc.), and 5) for cancer and virus. With potent promoters of plant's root growth in hand, the first dream is going now successfully. Preliminary experiments combating desertification at Gobi desert in Inner Mongolia are reported in detail, aiming for preventing global warming. © 2008 The Japan Institute of Heterocyclic Chemistry. 続きを見る

URL:

http://hdl.handle.net/2297/19324