Nucleophilic substitution reaction in indole chemistry: A synthesis of novel 7β-substituted yohimbine and 4aα-substituted 1,2,3,4-tetrahydro-β-carboline derivatives

Nucleophilic substitution reaction in indole chemistry: A synthesis of novel 7β-substituted yohimbine and 4aα-substituted 1,2,3,4-tetrahydro-β-carboline derivatives

フォーマット:

論文

責任表示:

Yoshino, Katsumasa ; Yamada, Fumio ; Somei, Masanori

言語:

英語

出版情報:

Japan Institute of Heterocyclic Chemistry = 日本複素環化学研究所, 2008-11-01

著者名:

掲載情報:

Heterocycles

ISSN:

0385-5414

巻:

76

通号:

2

開始ページ:

989

終了ページ:

994

バージョン:

author

概要:

金沢大学医薬保健研究域薬学系<br />金沢大学名誉教授<br />X-Ray analyses of 1-hydroxyyohimbine derivatives clearly show the deviation of the N(1)-O bond from the indole molecular plane. This phenomenon supports our working hypothesis "bishomoallyl … ic conjugation". The deviation is responsible for the unprecedented nucleophilic substitution reaction in 1-hydroxyindole chemistry and effected the synthesis of novel 7β-heteroarylyohimbine and 4aα-heteroaryl-1,2,3,4-tetrahydro-β-carboline derivatives from the corresponding 1-hydroxyindole derivatives. © 2008 The Japan Institute of Heterocyclic Chemistry All rights reserved. 続きを見る

URL:

http://hdl.handle.net/2297/19325

タイトル・著者・出版者が同じ資料

詳細

主題:	1-Hydroxyyohimbine; 7β-Heteroarylyohimbine; Nucleophilic Substitution; Tetrahydro-β-carboline
受理日:	2008-11-01

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