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An emerging strategy for cancer treatment targeting aberrant glycogen synthase kinase 3β
- フォーマット:
- 論文
- 責任表示:
- Miyashita, Katsuyoshi ; Nakada, Mitsutoshi ; Shakoori, Abbas ; Ishigaki, Yasuhito ; Shimasaki, Takeo ; Motoo, Yoshiharu ; Kawakami, Kazuyuki ; Minamoto, Toshinari
- 言語:
- 英語
- 出版情報:
- Bentham Science Publishers, 2009-01-01
- 著者名:
Miyashita, Katsuyoshi Nakada, Mitsutoshi Shakoori, Abbas Ishigaki, Yasuhito Shimasaki, Takeo Motoo, Yoshiharu Kawakami, Kazuyuki Minamoto, Toshinari - 掲載情報:
- Anti-Cancer Agents in Medicinal Chemistry
- ISSN:
- 1871-5206
- 巻:
- 9
- 通号:
- 10
- 開始ページ:
- 1114
- 終了ページ:
- 1122
- バージョン:
- author
- 概要:
- 金沢大学がん研究所分子標的がん医療研究開発センター<br />Improvement in the outcome of cancer patients who are refractory to currently available treatments relies on the development of target-directed therapies. One group of molecular targets with potential cl … inical relevance is a set of protein tyrosine kinases encoded mostly by proto-oncogenes and that are frequently deregulated in cancer. Glycogen synthase kinase 3β (GSK3β), a serine/threonine protein kinase, has emerged as a therapeutic target for common chronic diseases including type 2 diabetes mellitus, neurodegenerative disorders, inflammation and osteoporosis. This is based on its currently known functions and primary pathologic causalities. GSK3β has well characterized roles in the regulation of gene transcription and in oncogenic signaling. We have shown that deregulated GSK3β promotes gastrointestinal, pancreatic and liver cancers and glioblastomas. Furthermore, we have demonstrated that inhibition of GSK3β attenuates cancer cells survival and proliferation, induces cell senescence and apoptosis and sensitizes tumor cells to chemotherapeutic agents and ionizing radiation. This has led us to propose GSK3β as a potential therapeutic target in cancer. The anti-tumor effects of GSK3β inhibition are mediated by changes in the expression and phosphorylation of molecules critical to the regulation of cell cycling, proliferation and apoptosis and underlie the pathological role for GSK3β in cancer. Investigation of the mechanisms responsible for deregulation of GSK3β and the consequent downstream pathologic effects in cancer cells has shed light on the molecular pathways leading to tumorigenesis. This will allow exploration of novel therapeutic strategies for cancer that target aberrant GSK3β. © 2009 Bentham Science Publishers Ltd. 続きを見る
- URL:
- http://hdl.handle.net/2297/20399
類似資料:
Japanese Cancer Association / Blackwell Publishing Ltd | |
Japanese Cancer Association / Blackwell Publishing Ltd | |
American Association for Cancer Research | |
金沢大学がん研究所 = Kanazawa University Cancer Research Institute |
Kanazawa Association of Tumor Biologists / Cancer Research Institute, Kanazawa University |
金沢大学がん研究所 = Kanazawa University Cancer Research Institute |