Early prediction of histopathological tumor response to preoperative chemotherapy by Tc-99m MIBI imaging in bone and soft tissue sarcomas

フォーマット:

論文

責任表示:

Taki, Junichi ; Inaki, Anri ; Wakabayashi, Hiroshi ; Sumiya, Hisashi ; Tsuchiya, Hiroyuki ; Zen, Yoh ; Kinuya, Seigo

言語:

英語

出版情報:

Lippincott Williams & Wilkins, 2010-03-01

著者名:

Taki, Junichi

Inaki, Anri

Wakabayashi, Hiroshi

Sumiya, Hisashi

Tsuchiya, Hiroyuki

Zen, Yoh

Kinuya, Seigo

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掲載情報:

Clinical Nuclear Medicine

ISSN:

0363-9762      

巻:

35

通号:

3

開始ページ:

154

終了ページ:

159

バージョン:

author

概要:

金沢大学附属病院核医学診療科<br />PURPOSE: Tc-99m-methoxyisobutylisonitrile (MIBI) accumulates in only viable cells. In patients with bone and soft tissue sarcomas, preoperative chemotherapy is essential and the early prediction of the tumor respon … se to chemotherapy would be beneficial for the planning of treatment strategy. The purpose of this study was to assess whether the change of Tc-99m-MIBI images from the prechemotherapy state to the early to midportion of chemotherapy can predict the final histopathological tumor response as accurately as the change of imaging after completion of chemotherapy. METHODS: Seventy-three patients with bone and soft tissue sarcomas underwent Tc-99m-MIBI scintigraphy before chemotherapy and at least 2 times after the second or third or fifth course of chemotherapy. The changes of the tracer uptake (ΔUR) and perfusion (ΔPI) from prechemotherapy to postchemotherapy were compared with histologic response. RESULTS: The sensitivity, specificity, and accuracy for the prediction of effective chemotherapy in ΔPI were 88%, 83%, 85% after second, 85%, 72%, 78% after third, and 81%, 71%, 76% after 5th chemotherapy, and those in ΔUR were 88%, 83%, 85% after 2nd, 85%, 92%, 89% after 3rd, and 94%, 77%, 85% after fifth chemotherapy, respectively. The area under the receiver operator characteristic curve of the ΔPI after second, third, and fifth chemotherapy were similarly good (0.842, 0.858, 0.811, respectively) and those of ΔUR were similarly excellent (0.915, 0.936, 0.931, respectively). CONCLUSION: In patients with bone and soft tissue sarcomas, the change of Tc-99m-MIBI images from prechemotherapy to early to middle of chemotherapy can predict the final histopathological tumor response to chemotherapy as accurately as the change of Tc-99m-MIBI images from prechemotherapy to the completion of the preoperative chemotherapy. © 2010 by Lippincott Williams & Wilkins. 続きを見る

URL:

http://hdl.handle.net/2297/23484