黄連解毒湯およびその構成生薬の心・血管系に対する作用 : ほてり・顔面紅潮に対する有効性の検討

フォーマット:

論文

責任表示:

脇田, 広美 ; 宮本, 謙一

言語:

日本語

出版情報:

Medical and Pharmaceutical Society for WAKAN-YAKU = 和漢医薬学会, 2002-12-20

著者名:

• 脇田, 広美
• 宮本, 謙一

掲載情報:

Journal of traditional medicines = 和漢医薬学雑誌

ISSN:

1880-1447      

巻:

19

通号:

6

開始ページ:

230

終了ページ:

237

バージョン:

publisher

概要:

金沢大学附属病院薬剤部<br />The auricular blood flow in intact rats decreased maximally at 15min after administration of Oren-gedoku-to extract (1.0/kg, intraduodenal (i.d.)), although the heart rates and the blood pressure scarcely changed. In … rats pretreated intravenously with theophylline (5mg/kg), the auricular blood flow also decreased similarly after its administration, while the heart rate and the blood pressure decreased. The extract (0.35g/kg, i.d.) of Scutellariae Radix which is the main constituent of Oren-gedoku-to decreased the auricular blood flow, the heart rate, and the blood pressure. On the other hand, In rats pretreated with reserpine (5mg/kg, i.v.) 24hrs before the administration, the blood flow, heart rate and blood pressure were not hardly affected after administration of both Oren-gedoku-to and Scutellariae Radix. In the isolated right and left atria, and papillary muscle of rats, the frequency and the strength of contraction was not influenced with Oren-gedoku-to extract and its constituent plant extracts. In the isolated Langendorff's heart of rats, the left ventricular systolic maximum pressure and heart rate were not influenced with Oren-gedoku-to, although the coronary flow was slightly increased. The above results suggest that Oren-gedoku-to is useful in hotflush, because of its decreasing effects on auricular blood flow without cardiac function, and among the constituent plants of Oren-gedoku-to, Scutellariae Radix plays a main part. 続きを見る

URL:

http://hdl.handle.net/2297/23603