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Contribution of visceral adiposity and insulin resistance to metabolic risk factors in Japanese men
- フォーマット:
- 論文
- 責任表示:
- Oka, Rie ; Kobayashi, Junji ; Inazu, Akihiro ; Yagi, Kunimasa ; Miyamoto, Susumu ; Sakurai, Masaru ; Nakamura, Koshi ; Miura, Katsuyuki ; Nakagawa, Hideaki ; Yamagishi, Masakazu
- 言語:
- 英語
- 出版情報:
- Elsevier, 2010-05-01
- 著者名:
Oka, Rie Kobayashi, Junji Inazu, Akihiro Yagi, Kunimasa Miyamoto, Susumu Sakurai, Masaru Nakamura, Koshi Miura, Katsuyuki Nakagawa, Hideaki Yamagishi, Masakazu - 掲載情報:
- Metabolism: Clinical and Experimental
- ISSN:
- 0026-0495
- 巻:
- 59
- 通号:
- 5
- 開始ページ:
- 748
- 終了ページ:
- 754
- バージョン:
- author
- 概要:
- 金沢大学大学院医学系研究科<br />北陸中央病院内科<br />We investigated the relative impacts of visceral adiposity and insulin resistance on the metabolic risk profile in middle-aged Japanese men. A cross-sectional study was conducted in 636 nondiabet … ic Japanese men with a mean age of 51.6 years. Visceral adipose tissue (AT) was assessed using computed tomography, and insulin resistance was determined by the homeostasis model assessment of insulin resistance (HOMA-IR). Metabolic risk factors were diagnosed according to the National Cholesterol Education Program Adult Treatment Panel III metabolic syndrome criteria: (1) hypertriglyceridemia, (2) low high-density lipoprotein cholesterol, (3) hypertension, (4) impaired fasting glucose, and (5) impaired glucose tolerance. Visceral AT and HOMA-IR were significantly and positively correlated with each other (r = 0.41, P < .001). Using the 75th percentile value as a cut point, those with isolated large visceral AT showed significantly greater odds ratios for each of the 5 risk factors measured except impaired fasting glucose, whereas those with isolated high HOMA-IR showed significantly greater odds ratios for each of the 5 risk factors except hypertriglyceridemia and impaired glucose tolerance, compared with the control group. The combined group (increased visceral AT and HOMA-IR) had the highest odds ratios for all studied risk factors. On logistic regression analysis using visceral AT and HOMA-IR as continuous independent variables, they were each independently associated with most of the metabolic risk factors and their clustering. In conclusion, neither visceral AT nor HOMA-IR stands out as the sole driving force of the risk profile; each makes a significant contribution to metabolic abnormalities in Japanese men. © 2010 Elsevier Inc. All rights reserved. 続きを見る
- URL:
- http://hdl.handle.net/2297/23920
類似資料:
Japan Atherosclerosis Society = 日本動脈硬化学会 |
Japanese Society of Internal Medicine = 日本内科学会 |
2
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金沢大学つるま保健学会 = the Tsuruma Health Science Society, Kanazawa University |
Japanese Society of Internal Medicine = 日本内科学会 |
Japan Atherosclerosis Society = 日本動脈硬化学会 |
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Difference between Fasting and Nonfasting Triglyceridemia: the Influence of Waist Circumference.
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Asian Association for the Study of Diabetes / Wiley-Blackwell |