※一部利用できない機能があります
The virulence of mixed infection with Streptococcus constellatus and Fusobacterium nucleatum in a murine orofacial infection model
- フォーマット:
- 論文
- 責任表示:
- Kuriyama, Tomoari ; Nakagawa, Kiyomasa ; Kawashiri, Shuichi ; Yamamoto, Etsuhide ; Nakamura, Shinichi ; Karasawa, Tadahiro
- 言語:
- 英語
- 出版情報:
- Elsevier, 2000-10-01
- 著者名:
Kuriyama, Tomoari Nakagawa, Kiyomasa Kawashiri, Shuichi Yamamoto, Etsuhide Nakamura, Shinichi Karasawa, Tadahiro - 掲載情報:
- Microbes and Infection
- ISSN:
- 1286-4579
- 巻:
- 2
- 通号:
- 12
- 開始ページ:
- 1425
- 終了ページ:
- 1430
- バージョン:
- author
- 概要:
- 金沢大学大学院医学系研究科<br />Orofacial infections are usually polymicrobial, and it is the microbial interactions of pathogenic species that cause tissue destruction. In this study, the microbial interaction between Streptococcus constellatus a … nd Fusobacterium nucleatum was characterized using a murine orofacial infection model. A mixture of viable S. constellatus and F. nucleatum cells (both 2 × 108 CFU/mouse) was injected into the submandible; as a result, all of the test mice died. In contrast, none of the experimental animals monoinjected with either S. constellatus or F. nucleatum died (P < 0.001), indicating that the synergism between the two resulted in the virulence. When a mixture of viable S. constellatus cells and a culture filtrate of F. nucleatum was tested, lethality and the bacterial cell count per lesion were significantly enhanced as compared with monoinjections (P < 0.02). However, the virulence of F. nucleatum was not enhanced by infection of a culture filtrate of S. constellatus. The enhancement of virulence was observed even when viable S. constellatus cells and the culture filtrate of F. nucleatum were injected at separate sites. Heat treatment of the culture filtrate of F. nucleatum did not affect the enhancement. These results indicate that a heat-stable substance(s) produced by F. nucleatum contributes to the microbial synergy of S. constellatus and F. nucleatum in orofacial infections. 続きを見る
- URL:
- http://hdl.handle.net/2297/2454
類似資料:
Asian Association of Oral and Maxillofacial / Elsevier | |
金沢大学医薬保健研究域医学系 | |
American Society for Microbiology |
金沢大学十全医学会 |