Serum levels of KL-6 reflect disease activity of interstitial pneumonia associated with ANCA-related vasculitis

フォーマット:

論文

責任表示:

Iwata, Yasunori ; Wada, Takashi ; Furuichi, Kengo ; Kitagawa, Kiyoki ; Kokubo, Satoshi ; Kobayashi, Motoo ; Sakai, Norihiko ; Yoshimoto, Keiichi ; Shimizu, Miho ; Kobayashi, Kenichi ; Yokoyama, Hitoshi

言語:

英語

出版情報:

The Japanese Society of Internal Medicine = 日本内科学会, 2001-01-01

著者名:

Iwata, Yasunori

Wada, Takashi

Furuichi, Kengo

Kitagawa, Kiyoki

Kokubo, Satoshi

Kobayashi, Motoo

Sakai, Norihiko

Yoshimoto, Keiichi

Shimizu, Miho

Kobayashi, Kenichi

Yokoyama, Hitoshi

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掲載情報:

Internal Medicine

ISSN:

1080-6040      

巻:

40

通号:

11

開始ページ:

1093

終了ページ:

1097

バージョン:

publisher

概要:

金沢大学医薬保健研究域医学系<br />Objective. KL-6 is reported to be excreted from the lung alveolar and bronchial epithelial cells and may be a good marker for monitoring disease activity of interstitial pneumonia. This study was designed to ascert … ain the clinical significance of serum KL-6 levels in interstitial pneumonia associated with anti-neutrophil cytoplasmic antibody (ANCA)-related vasculitis. Methods. Serum KL-6 levels were determined by an enzyme-linked immunosorbent assay. Patients. We examined 20 healthy subjects, 13 patients with perinuclear (myeloperoxidase, MPO) ANCA-related vasculitis and 12 dermatomyositis (DM)/polymyositis (PM) patients as disease controls in this study. Six out of 13 patients with ANCA-related vasculitis had interstitial pneumonia. Results. Serum levels of KL-6 in ANCA-positive patients with interstitial pneumonia were significantly elevated, while they remained as low as those of healthy subjects in ANCA- positive patients without interstitial pneumonia. Similarly, KL-6 levels in sera were higher in 12 dermatomyositis/polymyositis patients with interstitial pneumonia, while they remained low in DM/PM patients without interstitial pneumonia. Moreover, the elevated serum KL-6 level was reduced during the convalescence induced by glucocorticoid therapy and reflected the disease activity of interstitial pneumonia associated with ANCA-related vasculitis. Conclusion. These data suggest that the measurement of serum KL-6 levels may be a good monitoring system for the diagnosis and follow-up of interstitial pneumonia of patients with ANCA-related vasculitis. 続きを見る

URL:

http://hdl.handle.net/2297/25634