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Metabolic disorder, inflammation, and deregulated molecular pathways converging in pancreatic cancer development: Implications for new therapeutic strategies
- フォーマット:
- 論文
- 責任表示:
- Motoo, Yoshiharu ; Shimasaki, Takeo ; Ishigaki, Yasuhito ; Nakajima, Hideo ; Kawakami, Kazuyuki ; Minamoto, Toshinari
- 言語:
- 英語
- 出版情報:
- MDPI Publishing, 2011-03-01
- 著者名:
Motoo, Yoshiharu Shimasaki, Takeo Ishigaki, Yasuhito Nakajima, Hideo Kawakami, Kazuyuki Minamoto, Toshinari - 掲載情報:
- Cancers
- ISSN:
- 2072-6694
- 巻:
- 3
- 通号:
- 1
- 開始ページ:
- 446
- 終了ページ:
- 460
- バージョン:
- publisher
- 概要:
- 金沢大学医薬保健研究域医学系<br />Pancreatic cancer develops and progresses through complex, cumulative biological processes involving metabolic disorder, local inflammation, and deregulated molecular pathways. The resulting tumor aggressiveness ha … mpers surgical intervention and renders pancreatic cancer resistant to standard chemotherapy and radiation therapy. Based on these pathologic properties, several therapeutic strategies are being developed to reverse refractory pancreatic cancer. Here, we outline molecular targeting therapies, which are primarily directed against growth factor receptor-type tyrosine kinases deregulated in tumors, but have failed to improve the survival of pancreatic cancer patients. Glycogen synthase kinase-3β (GSK3β) is a member of a serine/threonine protein kinase family that plays a critical role in various cellular pathways. GSK3β has also emerged as a mediator of pathological states, including glucose intolerance, inflammation, and various cancers (e.g., pancreatic cancer). We review recent studies that demonstrate the anti-tumor effects of GSK3β inhibition alone or in combination with chemotherapy and radiation. GSK3β inhibition may exert indirect anti-tumor actions in pancreatic cancer by modulating metabolic disorder and inflammation. © 2011 by the authors; licensee MDPI, Basel, Switzerland. 続きを見る
- URL:
- http://hdl.handle.net/2297/27790
類似資料:
Bentham Science Publishers | |
Japanese Cancer Association / Blackwell Publishing Ltd |
金沢大学がん研究所 = Kanazawa University Cancer Research Institute |
American Association for Cancer Research | |
International Federation for Cell Biology / Portland Press | |