Caffeine activates tumor suppressor PTEN in sarcoma cells

Caffeine activates tumor suppressor PTEN in sarcoma cells

フォーマット:

論文

責任表示:

Miwa, Shinji ; Sugimoto, Naotoshi ; Shirai, Toshiharu ; Hayashi, Katsuhiro ; Nishida, Hideji ; Ohnari, Issei ; Takeuchi, Akihiko ; Yachie, Akihiro ; Tsuchiya, Hiroyuki

言語:

英語

出版情報:

Spandidos Publications, 2011-04-01

著者名:

掲載情報:

International Journal of Oncology

ISSN:

1019-6439

巻:

39

通号:

2

開始ページ:

465

終了ページ:

472

バージョン:

author

概要:

金沢大学医薬保健研究域医学系<br />The tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a negative regulator of the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway. Akt activation exerts a strong anti-apo … ptotic effect and inhibits key pro-apoptotic proteins. We investigated the effect of caffeine in the prevention of tumor cell proliferation and induction of cell death. We found that caffeine induced increased intracellular cAMP levels, PTEN activation and Akt inactivation, which together prevented proliferation of human osteosarcoma cells (MG63) and fibrosarcoma cells (HT1080). PTEN knockdown by siRNA reduced the effects of caffeine on Akt inactivation in osteosarcoma cells. These results indicate that the tumor suppressor PTEN signaling pathway contributes to the growth-inhibitory effect of caffeine on sarcoma cells. Our data suggest that caffeine and other drugs that act on this pathway could have promising therapeutic effects in the treatment of sarcoma patients. 続きを見る

URL:

http://hdl.handle.net/2297/28572

タイトル・著者・出版者が同じ資料

詳細

主題:	Akt; Caffeine; PTEN; cAMP sarcoma
受理日:	2011-04-01

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1 論文 Activation of tumor suppressor protein PTEN and induction of apoptosis are involved in cAMP-mediated inhibition of cell number in B92 glial cells Sugimoto, Naotoshi, Miwa, Shinji, Ohno-Shosaku, Takako, Tsuchiya, Hiroyuki, Hitomi, Yoshiaki, Nakamura, Hiroyuki, … Elsevier	7 論文 Over 10-year follow-up of functional outcome in patients with bone tumors reconstructed using distraction osteogenesis Watanabe, Koji, Tsuchiya, Hiroyuki, Yamamoto, Norio, Shirai, Toshiharu, Nishida, Hideji, Hayashi, Katsuhiro, Takeuchi, … Japanese Orthopaedic Association 日本臨床整形外科学会 / Springer Verlag
2 論文 Caffeine-potentiated chemotherapy for clear cell sarcoma: a report of five cases Karita, Michiaki, Tsuchiya, Hiroyuki, Yamamoto, Norio, Shirai, Toshiharu, Hayashi, Katsuhiro, Nishida, Hideji Japan Society of Clinical Oncology = 日本癌治療学会 / Springer Verlag (Germany)	8 論文 Over 10-year follow-up of functional outcome in patients with bone tumors reconstructed using distraction osteogenesis Watanabe, Koji, Tsuchiya, Hiroyuki, Yamamoto, Norio, Shirai, Toshiharu, Nishida, Hideji, Hayashi, Katsuhiro, Takeuchi, … 日本整形外科学会 = Japanese Orthopaedic Association / Springer
3 論文 Activity of bone morphogenetic protein-7 after treatment at various temperatures: Freezing vs. pasteurization vs. allograft Takata, Munetomo, Sugimoto, Naotoshi, Yamamoto, Norio, Shirai, Toshiharu, Hayashi, Katsuhiro, Nishida, Hideji, Tanzawa, … Elsevier	9 論文 Protein kinase A and Epac activation by cAMP regulateS the expression of glial fibrillary acidic protein in glial cells Sugimoto, Naotoshi, Miwa, Shinji, Nakamura, Hiroyuki, Tsuchiya, Hiroyuki, Yachie, Akihiro Serbian Biological Society / Institut za Bioloska Istrazivanja
4 論文 High-grade undifferentiated pleomorphic sarcoma of pelvis treated with curettage and bone graft after complete remission following caffeine-potentiated … Tsuchiya, Hiroyuki, Takeuchi, Akihiko, Yamamoto, Norio, Shirai, Toshiharu, Hayashi, Katsuhiro, Nishida, Hideji, Tomita, … Springer Verlag	10 論文 Pedicle versus free frozen autograft for reconstruction in malignant bone and soft tissue tumors of the lower extremities Shimozaki, Shingo, Yamamoto, Norio, Shirai, Toshiharu, Nishida, Hideji, Hayashi, Katsuhiro, Tanzawa, Yoshikazu, Kimura, … Japanese Orthopaedic Association 日本整形外科学会 / Springer Verlag (Germany)
5 論文 High-grade undifferentiated pleomorphic sarcoma of pelvis treated with curettage and bone graft after complete remission following caffeine-potentiated … Tsuchiya, Hiroyuki, Takeuchi, Akihiko, Yamamoto, Norio, Shirai, Toshiharu, Hayashi, Katsuhiro, Nishida, Hideji, Tomita, … Springer Verlag (Germany) / The Japanese Orthopaedic Association	11 論文 The outcomes of reconstruction using frozen autograft combined with iodine-coated implants for malignant bone tumors: Compared with non-coated implants Shirai, Toshiharu, Tsuchiya, Hiroyuki, Terauchi, Ryu, Tsuchida, Shinji, Mizoshiri, Naoki, Igarashi, Kentaro, Miwa, … Oxford University Press
6 論文 Huge and deeply situated glomus tumor: Its malignant form Shirai, Toshiharu, Tsuchiya, Hiroyuki, Yamamoto, Norio, Hayashi, Katsuhiro, Nishida, Hideji, Takeuchi, Akihiko, Kimura, … Lippincott, Williams & Wilkins	12 論文 Knee joint preservation surgery in osteosarcoma using tumour-bearing bone treated with liquid nitrogen Higuchi, Takashi, Yamamoto, Norio, Nishida, Hideji, Hayashi, Katsuhiro, Takeuchi, Akihiko, Kimura, Hiroaki, Miwa, … Springer Verlag