Profile of rhythmic gene expression in the livers of obese diabetic KK-Ay mice

Profile of rhythmic gene expression in the livers of obese diabetic KK-Ay mice

フォーマット:

論文

責任表示:

Ando, Hitoshi ; Oshima, Yasuo ; Yanagihara, Hayato ; Hayashi, Yohei ; Takamura, Toshinari ; Kaneko, Shuichi ; Fujimura, Akio

言語:

英語

出版情報:

Elsevier, 2006-08-01

著者名:

掲載情報:

Biochemical and Biophysical Research Communications

ISSN:

0006-291x

巻:

346

通号:

4

開始ページ:

1297

終了ページ:

1302

バージョン:

author

概要:

金沢大学大学院医学系研究科環境社会医学<br />Although a number of genes expressed in most tissues, including the liver, exhibit circadian regulation, gene expression profiles are usually examined only at one scheduled time each day. In this study, we inv … estigated the effects of obese diabetes on the hepatic mRNA levels of various genes at 6-h intervals over a single 24-h period. Microarray analysis revealed that many genes are expressed rhythmically, not only in control KK mice but also in obese diabetic KK-Ay mice. Real-time quantitative PCR verified that 19 of 23 putative circadianly expressed genes showed significant 24-h rhythmicity in both strains. However, obese diabetes attenuated these expression rhythms in 10 of 19 genes. More importantly, the effects of obese diabetes were observed throughout the day in only two genes. These results suggest that observation time influences the results of gene expression analyses of genes expressed circadianly. © 2006 Elsevier Inc. All rights reserved. 続きを見る

URL:

http://hdl.handle.net/2297/2868

タイトル・著者・出版者が同じ資料

詳細

主題:	Circadian rhythm; Clock gene; Gene expression; Liver; Molecular clock; Obesity; Type 2 diabetes
受理日:	2006-08-01

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