Cytokine upregulation in tubulointerstitial nephritis associated with membranous nephropathy

フォーマット:

論文

責任表示:

Wada, Takashi ; Yokoyama, Hitoshi ; Sakai, Norihiko ; Izumiya, Yoshiaki ; Shimizu, Miho ; Furuichi, Kengo ; Segawa, Chikako ; Misaki, Tsuguho ; Kobayashi, Ken-ichi

言語:

英語

出版情報:

日本腎臓学会 = Japanese Society of Nephrology, 1999-01-01

著者名:

Wada, Takashi

Yokoyama, Hitoshi

Sakai, Norihiko

Izumiya, Yoshiaki

Shimizu, Miho

Furuichi, Kengo

Segawa, Chikako

Misaki, Tsuguho

Kobayashi, Ken-ichi

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掲載情報:

Clinical and Experimental Nephrology

ISSN:

1342-1751      

巻:

3

通号:

2

開始ページ:

130

終了ページ:

132

バージョン:

publisher

概要:

We describe the upregulation of cytokines in a 45-year-old woman with tubulointerstitial nephritis and membranous nephropathy revealed by renal biopsy. She was treated with a combination of prednisolone and cyclosporin. Histological findings showed appreciable improvement, and urinary protein excretion was decreased from 15 g/day to 1 g/day. Elevated urinary levels of chemokines, interleukin (IL)-8 and monocyte chemotactic and activating factor … (MCAF)/monocyte chemoattractant protein (MCP)-1, and serum levels of tumor necrosis factor (TNF)-α decreased during convalescence; 13 other patients with membranous nephropathy did not show elevation of these cytokines. These results suggest that the upregulation of these cytokines may participate in the pathogenesis of tubulointerstitial nephritis and that combination therapy of prednisolone and cyclosporin may be effective, possibly via inducing a decrease in these cytokines. 続きを見る

URL:

http://hdl.handle.net/2297/29243