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Identification of a secretory protein c19orf10 activated in hepatocellular carcinoma
- フォーマット:
- 論文
- 責任表示:
- Sunagozaka, Hajime ; Honda, Masao ; Yamashita, Taro ; Nishino, Ryuhei ; Takatori, Hajime ; Arai, Kuniaki ; Yamashita, Tatsuya ; Sakai, Yoshio ; Kaneko, Shuichi
- 言語:
- 英語
- 出版情報:
- Wiley-Blackwell, 2011-11-01
- 著者名:
Sunagozaka, Hajime Honda, Masao Yamashita, Taro Nishino, Ryuhei Takatori, Hajime Arai, Kuniaki Yamashita, Tatsuya Sakai, Yoshio Kaneko, Shuichi - 掲載情報:
- International Journal of Cancer
- ISSN:
- 0020-7136
- 巻:
- 129
- 通号:
- 7
- 開始ページ:
- 1576
- 終了ページ:
- 1585
- バージョン:
- author
- 概要:
- The identification of genes involved in tumor growth is crucial for the development of inventive anticancer treatments. Here, we have cloned a 17-kDa secretory protein encoded by c19orf10 from hepatocellular carcinoma (HCC) serial analysis of gene expression libraries. Gene expression analysis indicated that c19orf10 was overexpressed in approximately two-thirds of HCC tissues compared to the adjacent noncancerous liver tissues, and its expression was significantly … positively correlated with that of alpha-fetoprotein (AFP). Overexpression of c19orf10 enhanced cell proliferation of AFP-negative HLE cells, whereas knockdown of c19orf10 inhibited cell proliferation of AFP-positive Hep3B and HuH7 cells along with G1 cell cycle arrest. Supplementation of recombinant c19orf10 protein in culture media enhanced cell proliferation in HLE cells, and this effect was abolished by the addition of antibodies developed against c19orf10. Intriguingly, c19orf10 could regulate cell proliferation through the activation of Akt/mitogen-activated protein kinase pathways. Taken together, these data suggest that c19orf10 might be one of the growth factors and potential molecular targets activated in HCC. Copyright © 2010 UICC. 続きを見る
- URL:
- http://hdl.handle.net/2297/29268
類似資料:
Wiley-Blackwell | |
Japanese Cancer Association / Blackwell Publishing Ltd | |
European Association for the Study of the Liver / Elsevier | |
Blackwell Publishing / 日本肝臓学会 Japan Society of Hepatology | |