Augmented single-unit muscle sympathetic nerve activity in heart failure with chronic atrial fibrillation

フォーマット:

論文

責任表示:

Ikeda, Tatsunori ; Murai, Hisayoshi ; Kaneko, Shuichi ; Usui, Soichiro ; Kobayashi, Daisuke ; Nakano, Manabu ; Ikeda, Keiko ; Takashima, Shin-ichiro ; Kato, Takeshi ; Okajima, Masaki ; Furusho, Hiroshi ; Takamura, Masayuki

言語:

英語

出版情報:

The Physiological Society / Wiley-Blackwell, 2012-02-01

著者名:

Ikeda, Tatsunori

Murai, Hisayoshi

Kaneko, Shuichi

Usui, Soichiro

Kobayashi, Daisuke

Nakano, Manabu

Ikeda, Keiko

Takashima, Shin-ichiro

Kato, Takeshi

Okajima, Masaki

Furusho, Hiroshi

Takamura, Masayuki

続きを見る

掲載情報:

Journal of Physiology

ISSN:

0022-3751      

巻:

590

通号:

3

開始ページ:

509

終了ページ:

518

バージョン:

author

概要:

Atrial fibrillation (AF) is a common complication in heart failure (HF) patients. However, it remains unclear whether irregular ventricular response patterns induced by AF increase sympathetic nerve activity. We measured resting multi- and single-unit muscle sympathetic nerve activity (MSNA) in 21 age-matched HF patients with chronic AF (n= 11) rhythm or sinus rhythm (SR, n= 10). The multi-unit MSNA, which was expressed as total activity, was similar … between HF + AF patients and HF + SR patients. However, the single-unit MSNA in HF + AF patients was significantly greater than that in HF + SR patients (62 ± 9 spikes min -1vs. 42 ± 4 spikes min -1, P < 0.05). Moreover, the incidence of multiple firing of single-unit MSNA within a given burst was augmented in HF + AF patients as compared with HF + SR patients (48 ± 8%vs. 26 ± 3%, P < 0.01). A significant negative relationship was observed between the reduced diastolic pressure induced by a prolonged cardiac interval in AF subjects and single-unit MSNA frequency within one cardiac interval in each HF + AF subject. The firing characteristics of single-unit MSNA were different between HF patients with AF and HF patients with SR; particularly, those with a prolonged long RR interval showed multiple firings of single-unit MSNA. These findings suggest that AF per se leads to the instantaneous augmentation of single-unit MSNA induced by decreased diastolic pressure, which might partially contribute to disease progression in HF patients. © 2012 The Authors. The Journal of Physiology © 2012 The Physiological Society. 続きを見る

URL:

http://hdl.handle.net/2297/30371