Prognostic factors for acute myeloid leukemia patients with t(6;9)(p23;q34) who underwent an allogeneic hematopoietic stem cell transplant

Prognostic factors for acute myeloid leukemia patients with t(6;9)(p23;q34) who underwent an allogeneic hematopoietic stem cell transplant

フォーマット:

論文

責任表示:

Ishiyama, Ken ; Takami, Akiyoshi ; Kanda, Yoshinobu ; Nakao, Shinji ; Hidaka, Michihiro ; Maeda, Tetsuo ; Naoe, Tomoki ; Taniguchi, Shuichi ; Kawa, Keisei ; Nagamura, Tokiko ; Tabuchi, Ken ; Atsuta, Yoshiko ; Sakamaki, Hisashi

言語:

英語

出版情報:

Nature Publishing Group, 2012-03-01

著者名:

掲載情報:

Leukemia

ISSN:

0887-6924

巻:

26

通号:

3

開始ページ:

461

終了ページ:

464

バージョン:

author

概要:

We have recently reported that the outcome of acute myeloid leukemia (AML) patients with t(6;9)(p23;q34) who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) was comparable to that of patients with a normal karyotype … . We performed a further analysis regarding the prognostic factors for t(6;9)(p23;q34) AML patients who underwent a HSCT. Seven pediatric patients and 57 adult patients, transplanted between 1996 and 2007, were assessed in this study. The overall survival (OS) of the pediatric patients tended to be better than the OS of the adults, although there were no statistically significant differences. The present study focused on the adult patients revealed that the disease status at HSCT was the sole prognostic factor affecting the OS identified in the univariate analysis. A multivariate analysis showed that the disease status at HSCT and M2 in the FAB classification were extracted as the significant variables affecting the OS. The patients who were not in remission at HSCT and had non-FAB-M2 showed a poorer outcome; 6 deaths in the 9 patients were due to a relapse of the AML. These findings suggest that novel therapeutic approaches might be needed for patients with these poor prognostic factors.<br />発行後6か月より全文公開　続きを見る

URL:

http://hdl.handle.net/2297/30378

タイトル・著者・出版者が同じ資料

詳細

主題:	Allogeneic hematopoietic stem cell transplantation; acute myeloid leukemia; and prognostic factor; t(6;9)(p23;q34
受理日:	2012-03-01

類似資料:

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