Inverse correlation between serum levels of selenoprotein p and adiponectin in patients with type 2 diabetes

フォーマット:

論文

責任表示:

Misu, Hirofumi ; Ishikura, Kazuhide ; Kurita, Seiichiro ; Takeshita, Yumie ; Ota, Tsuguhito ; Saito, Yoshiro ; Takahashi, Kazuhiko ; Kaneko, Shuichi ; Takamura, Toshinari

言語:

英語

出版情報:

PLoS ONE, 2012-04-04

著者名:

Misu, Hirofumi

Ishikura, Kazuhide

Kurita, Seiichiro

Takeshita, Yumie

Ota, Tsuguhito

Saito, Yoshiro

Takahashi, Kazuhiko

Kaneko, Shuichi

Takamura, Toshinari

続きを見る

掲載情報:

PLoS ONE

ISSN:

1932-6203      

巻:

7

通号:

4

開始ページ:

e34952

バージョン:

publisher

概要:

Background: We recently identified selenoprotein P (SeP) as a liver-derived secretory protein that causes insulin resistance in the liver and skeletal muscle; however, it is unknown whether and, if so, how SeP acts on adipose tissue. The present study tested the hypothesis that SeP is related to hypoadiponectinemia in patients with type 2 diabetes. Methodology/Principal Findings: We compared serum levels of SeP with those of adiponectin and other … clinical parameters in 36 patients with type 2 diabetes. We also measured levels of blood adiponectin in SeP knockout mice. Circulating SeP levels were positively correlated with fasting plasma glucose (r = 0.35, P = 0.037) and negatively associated with both total and high-molecular adiponectin in patients with type 2 diabetes (r = -0.355, P = 0.034; r = -0.367, P = 0.028). SeP was a predictor of both total and high-molecular adiponectin, independently of age, body weight, and quantitative insulin sensitivity index (β = -0.343, P = 0.022; β = -0.357, P = 0.017). SeP knockout mice exhibited an increase in blood adiponectin levels when fed regular chow or a high sucrose, high fat diet. Conclusions/Significance: These results suggest that overproduction of liver-derived secretory protein SeP is connected with hypoadiponectinemia in patients with type 2 diabetes. © 2012 Misu et al. 続きを見る

URL:

http://hdl.handle.net/2297/31364