Autoimmune Cholangitis in the SJL/J Mouse is Antigen Non-specific

フォーマット:

論文

責任表示:

Sasaki, Motoko ; Allina, Jorge Joseph ; Odin, A. ; Thung, Swan N. ; Coppel, Ross ; Nakanuma, Yasuni ; Gershwin, Eric M.

言語:

英語

出版情報:

Hindawi Publishing Corporation, 2002-01-01

著者名:

Sasaki, Motoko

Allina, Jorge Joseph

Odin, A.

Thung, Swan N.

Coppel, Ross

Nakanuma, Yasuni

Gershwin, Eric M.

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掲載情報:

Developmental Immunology

巻:

9

通号:

2

開始ページ:

103

終了ページ:

111

バージョン:

publisher

概要:

Primary biliary cirrhosis (PBC) is an autoimmune disease characterized by intrahepatic bile duct destruction and the production of anti-mitochondrial antibodies (AMA). The absence of an animal model has been a striking impedance in defining the molecular basis of disease. Previous work has suggested that SJL/J mice immunize with the pyruvate dehydrogenase complex (PDC-E2), the major mitochondrial autoantigen of PBC, leads to the development of lymphoid cell … infiltration in portal tracts and a model system coined autoimmune cholangitis. We hypothesized that this pathology would be augmented if immunization occurred in the presence of IFN-γ injections. Accordingly, SJL/J mice were immunized with PDC-E2 and, for purpose of control, α-casein. Subgroups of mice were also treated with exogenous IFN-γ. As expected, mice immunized with PDC-E2, with or without IFN-γ, developed high titer AMAs. In contrast, mice immunized with α-casein, develop antinuclear antibodies. More importantly, the livers from mice immunized with PDC-E2 and/or those immunized with α-casein all displayed lymphoid cell infiltration to the portal tracts, irrespective of bile duct size. Indeed, there was no significant difference between the experimental and the control groups by histologic analysis. Thus, autoimmune cholangitis in these mice is antigen non-specific. 続きを見る

URL:

http://hdl.handle.net/2297/31500