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Pharmacokinetics and pharmacodynamics of insulin aspart in patients with Type 2 diabetes: Assessment using a meal tolerance test under clinical conditions

フォーマット:
論文
責任表示:
Ando, Hitoshi ; Kurita, Seiichiro ; Shimizu, Akiko ; Kato, Ken-ichiro ; Ishikura, Kazuhide ; Taji, Koumei ; Uno, Masafumi ; Takeshita, Yumie ; Misu, Hirofumi ; Fujimura, Akio ; Kaneko, Shuichi ; Takamura, Toshinari
言語:
英語
出版情報:
Blackwell, 2012-06-01
著者名:
Ando, Hitoshi
Kurita, Seiichiro
Shimizu, Akiko
Kato, Ken-ichiro
Ishikura, Kazuhide
Taji, Koumei
Uno, Masafumi
Takeshita, Yumie
Misu, Hirofumi
Fujimura, Akio
Kaneko, Shuichi
Takamura, Toshinari
続きを見る
掲載情報:
Clinical and Experimental Pharmacology and Physiology
ISSN:
0305-1870  CiNii Research  Webcat Plus  JAIRO
巻:
39
通号:
6
開始ページ:
528
終了ページ:
534
バージョン:
author
概要:
Few studies have evaluated the pharmacokinetics of rapid-acting insulin analogues in patients with Type 2 diabetes, especially under clinical conditions. The aim of the present study was to assess both the pharmacokinetics and pharmacodynamics of insulin aspart in Type 2 diabetic patients who were being treated with the analogue alone. Meal tolerance tests with and without self-injection of a customary dose of insulin aspart (0.05-0.22 U/kg) were conducted in 20 patients in a randomized cross-over study. The dose of insulin aspart (per bodyweight) was significantly correlated with both the maximum concentration (r 2 = 0.59; P < 0.01) and area under the concentration-time curve for insulin aspart (r 2 = 0.53; P < 0.01). However, the time to maximum concentration (T max), which varied widely from < 60 to ≥ 120 min, was not associated with either dosage (r 2 = 0.02; P = 0.51) or body mass index (r 2 = 0.02; P = 0.57). Injection of insulin aspart exacerbated delayed hyperinsulinaemia after meal loading, mainly in patients with T max ≥ 120 min. With regard to pharmacodynamics, insulin aspart had favourable effects on postprandial hyperglycaemia, hyperglucagonaemia and hyperlipidaemia. The T max for this insulin analogue differed greatly between individuals and delayed hyperinsulinaemia was particularly exacerbated in patients with higher T max values. Identification of the factors contributing to interindividual variation in the absorption lag time is essential for improving the efficacy and safety of insulin aspart. © 2012 The Authors. Clinical and Experimental Pharmacology and Physiology © 2012 Blackwell Publishing Asia Pty Ltd. 続きを見る
URL:
http://hdl.handle.net/2297/31973
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Blackwell Publishing