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Pharmacokinetics and pharmacodynamics of insulin aspart in patients with Type 2 diabetes: Assessment using a meal tolerance test under clinical conditions
- フォーマット:
- 論文
- 責任表示:
- Ando, Hitoshi ; Kurita, Seiichiro ; Shimizu, Akiko ; Kato, Ken-ichiro ; Ishikura, Kazuhide ; Taji, Koumei ; Uno, Masafumi ; Takeshita, Yumie ; Misu, Hirofumi ; Fujimura, Akio ; Kaneko, Shuichi ; Takamura, Toshinari
- 言語:
- 英語
- 出版情報:
- Blackwell, 2012-06-01
- 著者名:
Ando, Hitoshi Kurita, Seiichiro Shimizu, Akiko Kato, Ken-ichiro Ishikura, Kazuhide Taji, Koumei Uno, Masafumi Takeshita, Yumie Misu, Hirofumi Fujimura, Akio Kaneko, Shuichi Takamura, Toshinari - 掲載情報:
- Clinical and Experimental Pharmacology and Physiology
- ISSN:
- 0305-1870
- 巻:
- 39
- 通号:
- 6
- 開始ページ:
- 528
- 終了ページ:
- 534
- バージョン:
- author
- 概要:
- Few studies have evaluated the pharmacokinetics of rapid-acting insulin analogues in patients with Type 2 diabetes, especially under clinical conditions. The aim of the present study was to assess both the pharmacokinetics and pharmacodynamics of insulin aspart in Type 2 diabetic patients who were being treated with the analogue alone. Meal tolerance tests with and without self-injection of a customary dose of insulin aspart (0.05-0.22 U/kg) were … conducted in 20 patients in a randomized cross-over study. The dose of insulin aspart (per bodyweight) was significantly correlated with both the maximum concentration (r 2 = 0.59; P < 0.01) and area under the concentration-time curve for insulin aspart (r 2 = 0.53; P < 0.01). However, the time to maximum concentration (T max), which varied widely from < 60 to ≥ 120 min, was not associated with either dosage (r 2 = 0.02; P = 0.51) or body mass index (r 2 = 0.02; P = 0.57). Injection of insulin aspart exacerbated delayed hyperinsulinaemia after meal loading, mainly in patients with T max ≥ 120 min. With regard to pharmacodynamics, insulin aspart had favourable effects on postprandial hyperglycaemia, hyperglucagonaemia and hyperlipidaemia. The T max for this insulin analogue differed greatly between individuals and delayed hyperinsulinaemia was particularly exacerbated in patients with higher T max values. Identification of the factors contributing to interindividual variation in the absorption lag time is essential for improving the efficacy and safety of insulin aspart. © 2012 The Authors. Clinical and Experimental Pharmacology and Physiology © 2012 Blackwell Publishing Asia Pty Ltd. 続きを見る
- URL:
- http://hdl.handle.net/2297/31973
類似資料:
American Society for Biochemistry and Molecular Biology | |
Public Library of Science |
日本内科学会 = the Japanese Society of Internal Medicine |