Serum cytokeratin 18 as a biomarker for gastric cancer

Serum cytokeratin 18 as a biomarker for gastric cancer

フォーマット:

論文

責任表示:

Oyama, Katsunobu ; Fushida, Sachio ; Kinoshita, Jun ; Okamoto, Koichi ; Makino, Isamu ; Nakamura, Keishi ; Hayashi, Hironori ; Inokuchi, Masafumi ; Nakagawara, Hisatoshi ; Tajima, Hidehiro ; Fujita, Hideto ; Takamura, Hiroyuki ; Ninomiya, Itasu ; Kitagawa, Hirohisa ; Fujimura, Takashi ; Ohta, Tetsuo

言語:

英語

出版情報:

Springer-Verlag, 2013-11-01

著者名:

Nakagawara, Hisatoshi

掲載情報:

Clinical and Experimental Medicine

ISSN:

1591-8890

巻:

13

通号:

4

開始ページ:

289

終了ページ:

295

バージョン:

author

概要:

Cytokeratin 18 (CK18) fragments are released into circulation during epithelial cell death. M30 (reflects caspase-cleaved CK18 fragment) and M65 (reflects total CK18 fragment) enzyme-linked immunosorbent assay (ELISA) detect circulating CK18 fragments released during caspase-dependent or total cell death, respectively; thus, CK18 has the potential of being a biomarker for epithelial cancers. In the present study, we investigated the serum levels of M30 and M65 in patients with … gastric cancer, determined correlation of these levels with clinical features, and evaluated the usefulness of these enzymes as diagnostic and prognostic markers. We enrolled 54 gastric cancer patients and 12 healthy volunteers in this study. We measured the serum levels of M30 and M65 by quantitative ELISA. The levels of M30 and M65 in gastric cancer patients were significantly higher than those in healthy volunteers (P = 0.001, P < 0.001). The enzyme levels were elevated with the progress of gastric cancer. The sensitivity and specificity of M30 as a diagnostic marker were 67.5 and 90.9 %, respectively, and those of M65 were 70.1 and 90.9 %, respectively. The serum levels of M30 and M65 in patient with early gastric cancer were elevated in 38.1 and 66.7 %, respectively. Further, increased serum level of M65 is an independent indicator of poor prognosis (P = 0.036). The serum levels of M30 and M65 may be useful biomarkers for gastric cancer as diagnostic markers that can reflect the extent of cancer. Moreover, M65 levels can be used as a prognostic indicator. © 2012 Springer-Verlag. 続きを見る

URL:

http://hdl.handle.net/2297/32001

タイトル・著者・出版者が同じ資料

詳細

主題:	Biomarker; Cytokeratin 18; Gastric cancer; Serum M30 level; Serum M65 level
受理日:	2013-11-01

類似資料:

1

2

3

4

5

6

7

8

9

10

11

12

1 論文 Efficacy of pre-operative chemotherapy with docetaxel, cisplatin, and S-1 (DCS therapy) and curative resection for gastric cancer with pathologically positive … Oyama, Katsunobu, Fushida, Sachio, Kinoshita, Jun, Makino, Isamu, Nakamura, Keishi, Hayashi, Hironori, Nakagawara, … Wiley-Blackwell	7 論文 Learning of thoracoscopic radical esophagectomy: How can the learning curve be made short and flat? Ninomiya, Itasu, Osugi, Harushi, Tomizawa, Naoki, Fujimura, Takashi, Kayahara, Masato, Takamura, Hiroyuki, Fushida, … Wiley Periodicals / International Society for Diseases of the Esophagus
2 論文 Extravasated platelet aggregation in liver zone 3 may correlate with the progression of sinusoidal obstruction syndrome following living donor liver … Nakanuma, Shinichi, Miyashita, Tomoharu, Hayashi, Hironori, Tajima, Hidehiro, Takamura, Hiroyuki, Tsukada, Tomoya, … Spandidos Publications	8 論文 Multiple liver metastases of pancreatic solid pseudopapillary tumor treated with resection following chemotherapy and transcatheter arterial embolization: A … Tajima, Hidehiro, Takamura, Hiroyuki, Kitagawa, Hirohisa, Nakayama, Akira, Shoji, Masatoshi, Watanabe, Toshifumi, … Spandidos Publications
3 論文 VEGF is a target molecule for peritoneal metastasis and malignant ascites in gastric cancer: Prognostic significance of VEGF in ascites and efficacy of … Fushida, Sachio, Oyama, Katsunobu, Kinoshita, Jun, Yagi, Yasumichi, Okamoto, Kouichi, Tajima, Hidehiro, Ninomiya, Itasu, … Dove Medical Press Ltd.	9 論文 Angiotensin II enhances epithelial-to-mesenchymal transition through the interaction between activated hepatic stellate cells and the stromal cell-derived … Okamoto, Koichi, Tajima, Hidehiro, Nakanuma, Shinichi, Sakai, Seisho, Makino, Isamu, Kinoshita, Jun, Hayashi, Hironori, … Spandidos Publications
4 論文 Potential of extravasated platelet aggregation as a surrogate marker for overall survival in patients with advanced gastric cancer treated with preoperative … Saito, Hiroto, Fushida, Sachio, Miyashita, Tomoharu, Oyama, Katsunobu, Yamaguchi, Takahisa, Tsukada, Tomoya, Kinoshita, … BioMed Central	10 論文 Extravasated platelet aggregation in the livers of rats with drug-induced hepatic sinusoidal obstruction syndrome Hirata, Miki, Tajima, Hidehiro, Miyashita, Tomoharu, Miyata, Takashi, Nakanuma, Shinichi, Makino, Isamu, Hayashi, … Spandidos Publications
5 論文 Predictive factors for postoperative tachyarrhythmia after thoracoscopic esophagectomy and the usefulness of landiolol hydrochloride for its treatment Okamoto, Koichi, Ninomiya, Itasu, Maruzen, Shogo, Saito, Hiroto, Tsukada, Tomoya, Kinoshita, Jun, Makino, Isamu, … The Japan Esophageal Society, 日本食道学会 / Springer Japan	11 論文 Angiotensin II induces tumor progression and fibrosis in intrahepatic cholangiocarcinoma through an interaction with hepatic stellate cells Okamoto, Koichi, Tajima, Hidehiro, Ohta, Tetsuo, Nakanuma, Shinichi, Hayashi, Hironori, Nakagawara, Hisatoshi, Onishi, … Spandidos Publications
6 論文 Increased E-selectin in hepatic ischemia-reperfusion injury mediates liver metastasis of pancreatic cancer Yoshimoto, Katsuhiro, Tajima, Hidehiro, Ohta, Tetsuo, Okamoto, Koichi, Sakai, Seisho, Kinoshita, Jun, Furukawa, … Spandidos Publications	12 論文 Aprepitant plus granisetron and dexamethasone for prevention of chemotherapy-induced nausea and vomiting in patients with gastric cancer treated with S-1 plus … Oyama, Katsunobu, Fushida, Sachio, Kaji, Masahide, Takeda, Toshiya, Kinami, Shinichi, Hirono, Yasuo, Yoshimoto, … Japanese Society of Gastroenterology 日本消化器病学会 / Springer Verlag (Germany)