Management of postoperative hemorrhage associated with factor VIII inhibitor: report of a case

Management of postoperative hemorrhage associated with factor VIII inhibitor: report of a case

フォーマット:

論文

責任表示:

Onishi, Ichiro ; Kayahara, Masato ; Munemoto, Masayoshi ; Sakai, Seisho ; Makino, Isamu ; Hayashi, Hironori ; Nakagawara, Hisatoshi ; Tajima, Hidehiro ; Takamura, Hiroyuki ; Kitagawa, Hirohisa ; Tani, Takashi ; Ohta, Tetsuo

言語:

英語

出版情報:

Japan Surgical Society = 日本外科学会 / Springer, 2013-09-01

著者名:

Nakagawara, Hisatoshi

掲載情報:

Surgery Today

ISSN:

0941-1291

巻:

43

通号:

9

開始ページ:

1058

終了ページ:

1061

バージョン:

author

概要:

This report presents a case that was successfully treated for acquired factor VIII inhibitor after extensive visceral surgery. A 71-year-old male who underwent surgery for bile duct cancer had active bleeding in the abdominal drainage tube on postoperative day (POD) 5, and prolonged activated partial thromboplastin time (aPTT) was detected (83.1 s) on POD 7. An extensive coagulation work-up revealed factor VIII deficiency (1 %), and a diagnosis of an … acquired factor VIII deficiency was established when a factor VIII inhibitor of 8 Bethesda units was demonstrated. The patient was treated with activated prothrombin complex concentrate (aPCCs) and bloody discharge was stopped within 3 days. Inhibitor elimination was started using prednisolone on POD 20; rituximab, was administered on POD 74 and 81. Factor VIII inhibitor had disappeared by POD 124, and factor VIII (72 %) and aPTT recovered to 45.9 s. This case report demonstrated the efficacy of aPCCs and rituximab in the treatment of acquired hemophilia associated with visceral surgery. © 2012 Springer. 続きを見る

URL:

http://hdl.handle.net/2297/32465

タイトル・著者・出版者が同じ資料

詳細

主題:	Acquired hemophilia; Factor VIII inhibitor; Postoperative hemorrhage
受理日:	2013-09-01

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