光電容積脈波式血中アルコール濃度計測装置の開発: in vivo試験による予備的検討

フォーマット:

論文

責任表示:

山越, 健弘 ; 小川, 充洋 ; 松村, 健太 ; 板坂, 優希 ; 宮崎, 慎平 ; 山越, 康弘 ; Rolfe, Peter ; 廣瀬, 元 ; 山越, 憲一

言語:

日本語

出版情報:

Japanese Society for Medical and Biological Engineering = 日本生体医工学会 JSMBE, 2012-01-01

著者名:

山越, 健弘

小川, 充洋

松村, 健太

板坂, 優希

宮崎, 慎平

山越, 康弘

Rolfe, Peter

廣瀬, 元

山越, 憲一

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掲載情報:

Transactions of Japanese Society for Medical and Biological Engineering

ISSN:

1347-443x      

巻:

50

通号:

2

開始ページ:

237

終了ページ:

247

バージョン:

publisher

概要:

In this preliminary study, we examined in human volunteers the performance of the developed prototype device for non-invasive quantification of blood alcohol concentration (BAC) by near-infrared light which is highly transparent to the body. We aimed at applying the results to the final goal of developing a novel alcohol-based vehicle ignition-interlock device. Accumulating evidence shows that one of the ethyl alcohol absorption peaks in the near-infrared region is … present at 1,185 nm. We combined this with our recent development of a non-invasive optical method for blood glucose measurement, which we call pulse glucometry, using blood volume pulsations in a finger within a cardiac cycle. Thus, we developed a novel method, pulse alcometry, for non-invasive measurement of BAC. We calculated second derivative values of optical density (OD λ") to remove baseline over a band including three wavelengths, 1,150 nm, 1,185 nm, and 1,220 nm. Then, a simple linear regression analysis was performed with the measured OD λ" to predict BAC levels. In 3 healthy male volunteers, during alcohol intake and washout, periodic optical measurements using the present device were made simultaneously with collection of blood samples for in vitro BAC analysis. In leave-one-out cross validations within an individual, the measured BAC and the predicted BAC correlated well (r = 0.773~0.846, mean absolute error = 0.134~0.333mg/ml). We conclude that, from the results of this preliminary study, the new method appears to be able to estimate BAC levels non-invasively. However, further investigations in a larger group of subjects will be needed in order to determine fully the operational performance of this new measurement system. 続きを見る

URL:

http://hdl.handle.net/2297/32473