A personal view from a long-lasting collaborator on the research strategies of Marshall Nirenberg

フォーマット:

論文

責任表示:

Higashida, Haruhiro

言語:

英語

出版情報:

Elsevier, 2012-11-01

著者名:

Higashida, Haruhiro  

掲載情報:

Neurochemistry International

ISSN:

0197-0186      

巻:

61

通号:

6

開始ページ:

821

終了ページ:

827

バージョン:

author

概要:

In this review, I summarized transition in Dr. Marshall Nirenberg's research interests during 1970s, from a view of a long-lasting collaborator. Nirenberg switched his research filed to neurobiology after his success in deciphering genetic code and being honored with the Nobel Prize in Physiology or Medicine in 1968. His targets were to obtain genetically pure population of neurons, i.e. neuroblastoma clones, to make somatic hydrid cells, to culture … neuronal and muscle cells, and to produce monoclonal antibodies against whole retinal or neuroblastoma cells. He studied neurotransmitters, receptors, cyclic nucleotides, cell differentiation, secretion, synapse formation, and chemical recognition. Especially he liked his hypothesis for opiate tolerance and dependency as a model of cellular memory. Through these studies, he seemed to devote all his time of about 50 years from 1960s to decoding brain memory processes. © 2011 Elsevier Ltd. All rights reserved. 続きを見る

URL:

http://hdl.handle.net/2297/32814