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Sphingosine-1-phosphate as a mediator involved in development of fibrotic diseases
- フォーマット:
- 論文
- 責任表示:
- Takuwa, Yoh ; Ikeda, Hitoshi ; Okamoto, Yasuo ; Takuwa, Noriko ; Yoshioka, Kazuaki
- 言語:
- 英語
- 出版情報:
- Elsevier, 2013-01-01
- 著者名:
- 掲載情報:
- Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
- ISSN:
- 1388-1981
- 巻:
- 1831
- 通号:
- 1
- 開始ページ:
- 185
- 終了ページ:
- 192
- バージョン:
- author
- 概要:
- Fibrosis is a pathological process characterized by massive deposition of extracellular matrix (ECM) such as type I/III collagens and fibronectin that are secreted by an expanded pool of myofibroblasts, which are phenotypically altered fibroblasts with more contractile, proliferative, migratory and secretory activities. Fibrosis occurs in various organs including the lung, heart, liver and kidney, resulting in loss of normal tissue architecture and functions. … Myofibroblasts could originate from multiple sources including tissue-resident fibroblasts, epithelial and endothelial cells through mechanisms of epithelial/endothelial-mesenchymal transition (EMT/EndMT), and bone marrow-derived circulating progenitors called fibrocytes. Emerging evidence in recent years shows that sphingosine-1-phosphate (S1P) acts on several types of target cells and is engaged in pro-fibrotic inflammatory process and fibrogenic process through multiple mechanisms, which include vascular permeability change, leukocyte infiltration, and migration, proliferation and myofibroblast differentiation of fibroblasts. Many of these S1P actions are receptor subtype-specific. In these actions, S1P has multiple cross-talks with other cytokines, particularly transforming growth factor-β (TGFβ), which plays a major role in fibrosis. The cross-talks include the regulation of S1P production through altered expression and activity of sphingosine kinases in fibrotic lesions, altered expression of S1P receptors, and S1P receptor-mediated transactivation of TGFβ signaling pathway. These cross-talks may give rise to a feed-forward, amplifying loop between S1P and TGFβ, and possibly with other cytokines in stimulating fibrogenesis. Another lysophospholipid mediator lysophosphatidic acid has also been recently implicated in fibrosis. The lysophospholipid signaling pathways represent novel, promising therapeutic targets for treating refractory fibrotic diseases. This article is part of a Special Issue entitled Advances in Lysophospholipid Research. © 2012 Elsevier B.V. 続きを見る
- URL:
- http://hdl.handle.net/2297/32827
類似資料:
International Union of Biochemistry and Molecular Biology, Inc / Wiley-Blackwell | |
International Union of Biochemistry and Molecular Biology, Inc. / Wiley-Blackwell | |
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American Society for Biochemistry and Molecular Biology |