Metabolic syndrome is not a predictor for cardiovascular events in Japanese patients with diabetes mellitus asymptomatic for coronary artery disease: A retrospective analysis of the J-ACCESS-2 study

フォーマット:

論文

責任表示:

Nakajima, Kenichi ; Takeishi, Yasuchika ; Matsuo, Shinro ; Yamasaki, Yoshimitsu ; Nishimura, Tsunehiko

言語:

英語

出版情報:

American Society of Nuclear Cardiology (ASNC) / Springer Verlag (Germany), 2013-04-01

著者名:

• Nakajima, Kenichi
• Takeishi, Yasuchika
• Matsuo, Shinro
• Yamasaki, Yoshimitsu
• Nishimura, Tsunehiko

掲載情報:

Journal of Nuclear Cardiology

ISSN:

1071-3581      

巻:

20

通号:

2

開始ページ:

234

終了ページ:

241

バージョン:

author

概要:

Purpose: Patients with metabolic syndrome (MetS) have potentially higher risk for cardiovascular events. The aim of this study was to evaluate the effect of MetS on cardiac events in type-2 diabetic patients asymptomatic for coronary artery disease (CAD) in a Japanese population. Methods: A total of 485 patients from a J-ACCESS-2 investigation with stress-gated myocardial perfusion imaging (MPI) and quantitative-gated MPI analysis were examined. Cardiovascular hard … events (cardiac death and acute coronary syndrome) and total events during a 3-year follow-up were analyzed. Results: The MetS group (n = 229) had higher incidence of hypertension, dyslipidemia, and ventricular dilatation than the non-MetS group (n = 256). The hard events were 8 and 12 for the MetS and non-MetS groups (P = n.s.), and total events were 31 and 31 for each of these groups, respectively (P = n.s.). Significant variables related to total cardiovascular events included age, current smoking, insulin use, total cholesterol, ejection fraction, summed stress score ≥ 9, and summed difference score ≥ 2. Cox proportional hazard analysis and Kaplan-Meier survival analysis showed that only the summed stress score was related to total events (P = .01), and the presence and the number of items for MetS criteria were not. Conclusion: In patients with type 2 diabetes asymptomatic for CAD, cardiovascular events and ischemia are as common in diabetic patients without MetS as in those with MetS. A high MPI defect score is related to total events including cardiac and cerebrovascular events. © 2012 American Society of Nuclear Cardiology. 続きを見る

URL:

http://hdl.handle.net/2297/33408