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Evaluation of a new histologic staging and grading system for primary biliary cirrhosis in comparison with classical systems

フォーマット:
論文
責任表示:
Kakuda, Yuko ; Harada, Kenichi ; Sawada-Kitamura, Seiko ; Ikeda, Hiroko ; Sato, Yasunori ; Sasaki, Motoko ; Okafuji, Hirofumi ; Mizukoshi, Eishiro ; Terasaki, Shuichi ; Ohta, Hajime ; Kasashima, Satomi ; Kawashima, Atsuhiro ; Kaizaki, Yasuharu ; Kaneko, Shuichi ; Nakanuma, Yasuni
言語:
英語
出版情報:
Elsevier, 2013-06-01
著者名:
Kakuda, Yuko
Harada, Kenichi
Sawada-Kitamura, Seiko
Ikeda, Hiroko
Sato, Yasunori
Sasaki, Motoko
Okafuji, Hirofumi
Mizukoshi, Eishiro
Terasaki, Shuichi
Ohta, Hajime
Kasashima, Satomi
Kawashima, Atsuhiro
Kaizaki, Yasuharu
Kaneko, Shuichi
Nakanuma, Yasuni
続きを見る
掲載情報:
Human Pathology
ISSN:
0046-8177  CiNii Research  Webcat Plus  JAIRO
巻:
44
通号:
6
開始ページ:
1107
終了ページ:
1117
バージョン:
author
概要:
Recently, our research team proposed a new histologic staging and grading system for primary biliary cirrhosis (PBC) that takes into account necroinflammatory activity and histologic heterogeneity. The present study aimed to confirm the usefulness of the new evaluation system. A total of 152 liver biopsy specimens and clinical data (including outcomes in patients with PBC before treatment with ursodeoxycholic acid) were analyzed with respect to the new system. Staging was evaluated on the basis of 3 histologic components (fibrosis, bile duct loss, and deposition of orcein-positive granules), and grading was assessed on the basis of chronic cholangitis activity and hepatitis activity. Concurrently, the classical systems, that is, the Scheuer and Ludwig staging systems, were also assessed and compared with our new system. PBC cases showed different distributions in each stage of the 3 systems. The new staging and grading system reflected liver dysfunctions before specific treatment. This was on a par with the results obtained using the classical systems. Development of cirrhosis-related conditions correlated well with the new staging system compared with the 2 classical staging systems, and in particular, the amount of deposition of orcein-positive granules could reflect development of cirrhosis-related conditions (scores 0-1 versus scores 2-3 groups, P < .0001). In conclusion, the new PBC staging system was demonstrated to reflect clinicolaboratory features, and its progression was associated with the development of cirrhosis-related conditions. © 2013 Elsevier Inc. All rights reserved. 続きを見る
URL:
http://hdl.handle.net/2297/33483
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