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Innate immunity in the pathogenesis of cholangiopathy: A recent update
- フォーマット:
- 論文
- 責任表示:
- Harada, Kenichi ; Nakanuma, Yasuni
- 言語:
- 英語
- 出版情報:
- Bentham Science Publishers, 2012-12-01
- 著者名:
- 掲載情報:
- Inflammation and Allergy - Drug Targets
- ISSN:
- 1871-5281
- 巻:
- 11
- 通号:
- 6
- 開始ページ:
- 478
- 終了ページ:
- 483
- バージョン:
- author
- 概要:
- Biliary innate immunity is involved in the pathogenesis of cholangiopathies in patients with various biliary diseases. Biliary epithelial cells possess an innate immune system consisting of the Toll-like receptor (TLR) family and recognize pathogen-associated molecular patterns (PAMPs). Recently, regulatory mechanisms by intracellular negative regulators including peroxisome proliferator-activated receptor-γ and micro-RNA have been clarified. In … primary biliary cirrhosis (PBC) and primary sclerosing cholangitis, dysregulated biliary innate immunity, namely hyper-responsiveness to PAMPs, is associated with the histopathogenesis of cholangiopathy. Moreover, biliary epithelial cells produce monocyte chemotactic protein-1 (MCP-1/CCL2) as a result of the innate immune response and bile ductules play a role in hepatic fibrosis caused by hepatic stellate cells (HSCs). Also, biliary innate immune responses induce the production of two chemokines, fractalkine and macrophage inflammatory protein-3α (MIP-3α), causing the migration of inflammatory cells and a population of antigen-presenting cell found in epithelium, Langerhans cell, and involve chronic cholangitis associated with biliary epithelium-specific innate and acquired immunity in PBC. © 2012 Bentham Science Publishers. 続きを見る
- URL:
- http://hdl.handle.net/2297/33484
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Japan Society of Hepatology / Wiley | |
British Society for Immunology / Wiley-Blackwell |
Taylor & Francis |
Blackwell Publishing |
Springer Science+Business Media |
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Baishideng Publishing Group Co |
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日本内科学会 = Japanese Society of Internal Medicine |