Expression of seven-in-absentia homologue 1 and hypoxia-inducible factor 1 alpha: Novel prognostic factors of nasopharyngeal carcinoma

Expression of seven-in-absentia homologue 1 and hypoxia-inducible factor 1 alpha: Novel prognostic factors of nasopharyngeal carcinoma

フォーマット:

論文

責任表示:

Kitagawa, Noriko ; Kondo, Satoru ; Wakisaka, Naohiro ; Zen, Yoh ; Nakanishi, Yosuke ; Tsuji, Akira ; Endo, Kazuhira ; Murono, Shigeyuki ; Yoshizaki, Tomokazu

言語:

英語

出版情報:

Elsevier, 2013-04-30

著者名:

掲載情報:

Cancer Letters

ISSN:

0304-3835

巻:

331

通号:

1

開始ページ:

52

終了ページ:

57

バージョン:

author

概要:

Nasopharyngeal carcinoma (NPC) is an EBV-associated cancer. We analysed Siah1 expression as well as LMP1 and HIF1α expression by immuno-histochemical staining in 74 NPC biopsy specimens and found that the expression of Siah1 was significantly correlated with advanced tumour status and stage. Moreover, Siah1-positive and HIF1α-positive cases had significantly worse prognoses. The expression score for LMP1 was remarkably correlated with that of Siah1, … whereas there was little correlation between LMP1 expression and the other markers evaluated. This is the first study to evaluate the pattern and clinical significance of Siah1 and HIF1α expression in NPC, and such an evaluation is valuable for identifying those patients at a high risk for a poor prognosis. © 2012 Elsevier Ireland Ltd. 続きを見る

URL:

http://hdl.handle.net/2297/34135

タイトル・著者・出版者が同じ資料

詳細

主題:	Epstein-Barr virus (EBV); Hypoxia-inducible factor 1 alpha (HIF1α); Latent membrane protein 1 (LMP1); Nasopharyngeal carcinoma; Seven-in-absentia homologue 1 (Siah1)
受理日:	2013-04-30

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