Association of the C825T polymorphism of the G-protein β3 subunit gene with hypertension, obesity, hyperlipidemia, insulin resistance, diabetes, diabetic complications, and diabetic therapies among Japanese

フォーマット:

論文

責任表示:

Hayakawa, Tetsuo ; Takamura, Toshinari ; Abe, Toshio ; Kaneko, Shuichi

言語:

英語

出版情報:

Elsevier BV, 2007-01-01

著者名:

• Hayakawa, Tetsuo
• Takamura, Toshinari
• Abe, Toshio
• Kaneko, Shuichi

掲載情報:

Metabolism: Clinical and Experimental

ISSN:

0026-0495      

巻:

56

通号:

1

開始ページ:

44

終了ページ:

48

バージョン:

author

概要:

金沢大学大学院医学系研究科環境社会医学<br />A C825T polymorphism of the gene encoding the G-protein β3 subunit (GNB3) is associated with increased intracellular signal transduction. We know that this C825T polymorphism may influence hypertension an … d obesity. In whites, the C825T polymorphism has been reported to induce hypertension, obesity, and diabetic nephropathy. Thus, we investigated how genetic variation in the GNB3 gene is associated with hypertension, obesity, insulin resistance, diabetes, diabetic complications, and diabetic therapies in 427 Japanese subjects with type 2 diabetes mellitus and in 368 Japanese subjects who underwent general health examinations. The frequency of the GNB3 gene polymorphism was 0.48 and 0.47 in subjects with diabetes and in those who had general health examinations, respectively. The amount of hyperlipidemia of the CT allele was significantly lower than the amount in the CC allele in the Japanese subjects with diabetes. Our results suggest that the C825T polymorphism influences lipid metabolism and is not associated with hypertension, obesity, insulin resistance, diabetes, diabetic complications, or diabetic therapies. © 2007. 続きを見る

URL:

http://hdl.handle.net/2297/3469