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局所麻酔薬ropivacaineのα_1-酸性糖タンパク結合動態と薬物間相互作用の検討
- フォーマット:
- 論文
- 責任表示:
- 石崎, 純子 ; 下村, 祥子 ; 福和, 千恵 ; 嶋田, 努 ; 横川, 弘一 ; 宮本, 謙一
- 言語:
- 日本語
- 出版情報:
- 日本医療薬学会 = Japanese Society of Pharmaceutical Health Care and Sciences, 2005-06-10
- 著者名:
石崎, 純子 下村, 祥子 福和, 千恵 嶋田, 努 横川, 弘一 宮本, 謙一 - 掲載情報:
- 医療薬学 = Japanese Journal of Pharmaceutical Health Care and Sciences
- ISSN:
- 1346-342x
- 巻:
- 31
- 通号:
- 6
- 開始ページ:
- 445
- 終了ページ:
- 450
- バージョン:
- publisher
- 概要:
- We examined the influence of basic drugs and protein variants on the binding disposition of ropivacaine to α1-acid glycoprotein (AGP). On doing this, we found the values of the competitive inhibition constant (Ki) for dipyridamole, verapamil, lidocaine and disopyramide with respect to the binding of ropivacaine to commercial AGP (70 mg/dL) to be 2.1, 5.2, 6.0 and 11.0μM, respectively. Also, there was a strong correlation between the fu value and the … AGP concentration when ropivacaine was added to plasma samples from ten healthy volunteers (r=0.861). Among the volunteers, eight showed F1S variants and two showed F1 variants without the S variant of AGP. There was no difference in the fu value of ropivacaine between these two groups. However, when ropivacaine was added together with dipyridamole, the fu values of ropivacaine in plasma from volunteers with ES variants were clearly higher than those from volunteers without the S variant. When ropivacaine was added together with disopyramide or lidocaine, however, there was no difference in fu values between these variants. Our results indicate that variability in the effectiveness and/or adverse effects of ropivacaine are caused by changes in fu as a consequence of changes in AGP concentration. They also suggest that in combination therapy, it is also important to consider the AGP variant-dependence of the inhibitory effect of concomitantly administered drugs. 続きを見る
- URL:
- http://hdl.handle.net/2297/36332
類似資料:
日本医療薬学会 = Japanese Society of Pharmaceutical Health Care and Sciences |
日本臨床麻酔学会 = The Japan Society for Clinical Anesthesia |
日本医療薬学会 |
金沢大学十全医学会 = The Juzen Medical Society Kanazawa University |
Pharmaceutical Society of Japan = 日本薬学会 |
日本臨床麻酔学会 = The Japan Society for Clinical Anesthesia |
[嶋田努] |
坂田篤 |
中山書店 |
金沢大学 |
金沢大学 |
日本薬学会 = The Pharmaceutical Society of Japan |