Prevalence and risk factors of hepatocellular carcinoma in Japanese patients with primary biliary cirrhosis

フォーマット:

論文

責任表示:

Harada, Kenichi ; Nakanuma, Yasuni

言語:

英語

出版情報:

Japan Society of Hepatology / Wiley, 2014-02-01

著者名:

• Harada, Kenichi
• Nakanuma, Yasuni

掲載情報:

Hepatology Research

ISSN:

1386-6346      

巻:

44

通号:

2

開始ページ:

133

終了ページ:

140

バージョン:

author

概要:

Primary biliary cirrhosis (PBC) tends to affect females more than males. PBC selectively damages intrahepatic small bile ducts, particularly interlobular bile ducts. The clinical presentation of PBC has changed according to recent advances in clinicobiological diagnosis and improvements in therapeutic effects and prognosis. In particular, we encounter PBC patients with hepatocellular carcinoma (HCC), and the number of these patients appears to have increased. The … precise reason for the increased number of PBC patients with HCC in recent decades remains unknown, but recognizing the current status of carcinogenesis in PBC patients, identifying the associated clinicopathological risk factors and understanding how the pathogenesis of PBC is directly associated with HCC, is important. In this review, we summarize the data from two nationwide surveys undertaken in Japan as well as recent data from Japanese and international studies. © 2013 The Japan Society of Hepatology. 続きを見る

URL:

http://hdl.handle.net/2297/36986