LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance

LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance

フォーマット:

論文

責任表示:

Lan, Fei ; Misu, Hirofumi ; Chikamoto, Keita ; Takayama, Hiroaki ; Kikuchi, Akihiro ; Mohri, Kensuke ; Takata, Noboru ; Hayashi, Hiroto ; Matsuzawa-Nagata, Naoto ; Takeshita, Yumie ; Noda, Hiroyo ; Matsumoto, Yukako ; Ota, Tsuguhito ; Nagano, Toru ; Nakagen, Masatoshi ; Miyamoto, Ken-ichi ; Takatsuki, Kanako ; Seo, Toru ; Iwayama, Kaito ; Tokuyama, Kunpei ; Matsugo, Seiichi ; Tang, Hong ; Saito, Yoshiro ; Yamagoe, Satoshi ; Kaneko, Shuichi ; Takamura, Toshinari

言語:

英語

出版情報:

American Diabetes Association, 2014-05-01

著者名:

掲載情報:

Diabetes

ISSN:

1939-327x

巻:

63

通号:

5

開始ページ:

1649

終了ページ:

1664

バージョン:

author

概要:

Recent articles have reported an association between fatty liver disease and systemic insulin resistance in humans, but the causal relationship remains unclear. The liver may contribute to muscle insulin resistance by releasing secretory proteins called hepatokines. Here we demonstrate that leukocyte cell-derived chemotaxin 2 (LECT2), an energy-sensing hepatokine, is a link between obesity and skeletal muscle insulin resistance. Circulating LECT2 … positively correlated with the severity of both obesity and insulin resistance in humans. LECT2 expression was negatively regulated by starvation-sensing kinase adenosine monophosphate-activated protein kinase in H4IIEC hepatocytes. Genetic deletion of LECT2 in mice increased insulin sensitivity in the skeletal muscle. Treatment with recombinant LECT2 protein impaired insulin signaling via phosphorylation of Jun NH2-terminal kinase in C2C12 myocytes. These results demonstrate the involvement of LECT2 in glucose metabolism and suggest that LECT2 may be a therapeutic target for obesity-associated insulin resistance. © 2014 by the American Diabetes Association. 続きを見る

URL:

http://hdl.handle.net/2297/37595

タイトル・著者・出版者が同じ資料

詳細

受理日:	2014-05-01

類似資料:

1

2

3

4

5

6

7

8

9

10

11

12

1 論文 Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells Ishikura, Kazuhide, Misu, Hirofumi, Kumazaki, Masafumi, Takayama, Hiroaki, Matsuzawa-Nagata, Naoto, Tajima, Natsumi, … Springer Verlag	7 学位論文 LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance 蘭, 菲, Lan, Fei
2 論文 A liver-derived secretory protein, selenoprotein P, causes insulin resistance Misu, Hirofumi, Takamura, Toshinari, Takayama, Hiroaki, Hayashi, Hiroto, Matsuzawa-Nagata, Naoto, Kurita, Seiichiro, … Elsevier	8 学位論文 LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance 蘭, 菲, Lan, Fei
3 論文 Inverse correlation between serum levels of selenoprotein p and adiponectin in patients with type 2 diabetes Misu, Hirofumi, Ishikura, Kazuhide, Kurita, Seiichiro, Takeshita, Yumie, Ota, Tsuguhito, Saito, Yoshiro, Takahashi, … PLoS ONE	9 学位論文マウスにおける食事誘導性体重変化時の脂肪肝感知ヘパトカイン LECT2 の急速な反応近本, 啓太, Chikamoto, Keita
4 論文 Ectopic fat accumulation and distant organ-specific insulin resistance in Japanese people with nonalcoholic fatty liver disease Kato, Ken-ichiro, Takamura, Toshinari, Takeshita, Yumie, Ryu, Yasuji, Misu, Hirofumi, Ota, Tsuguhito, Tokuyama, Kumpei, … Public Library of Science	10 学位論文マウスにおける食事誘導性体重変化時の脂肪肝感知ヘパトカイン LECT2 の急速な反応近本, 啓太, Chikamoto, Keita
5 論文 Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria. Nakamura, Seiji, Takamura, Toshinari, Matsuzawa-Nagata, Naoto, Takayama, Hiroaki, Misu, Hirofumi, Noda, Hiroyo, … American Society for Biochemistry and Molecular Biology	11 論文 Time Course Effect of R-Alpha-Lipoic Acid on Cellular Metabolomics in Cultured Hepatoma Cells Ikuta, Naoko, Chikamoto, Keita, Asano, Yuya, Yasui, Yoshiaki, Yokokawa, Haruka, Terao, Keiji, Rimbach, Gerald, Matsugo, … Mary Ann Liebert Inc.
6 論文 Metformin Prevents and Reverses Inflammation in a Non-Diabetic Mouse Model of Nonalcoholic Steatohepatitis Kita, Yuki, Takamura, Toshinari, Misu, Hirofumi, Ota, Tsuguhito, Kurita, Seiichiro, Takeshita, Yumie, Uno, Masafumi, … Public Library of Science	12 論文 Tumor necrosis factor-α-induced production of plasminogen activator inhibitor 1 and its regulation by pioglitazone and cerivastatin in a nonmalignant human … Takeshita, Yumie, Takamura, Toshinari, Hamaguchi, Erika, Shimizu, Akiko, Ota, Tsuguhito, Sakurai, Masaru, Kaneko, … Elsevier BV