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Ectopic fat accumulation and distant organ-specific insulin resistance in Japanese people with nonalcoholic fatty liver disease
- フォーマット:
- 論文
- 責任表示:
- Kato, Ken-ichiro ; Takamura, Toshinari ; Takeshita, Yumie ; Ryu, Yasuji ; Misu, Hirofumi ; Ota, Tsuguhito ; Tokuyama, Kumpei ; Nagasaka, Shoichiro ; Matsuhisa, Munehide ; Matsui, Osamu ; Kaneko, Shuichi
- 言語:
- 英語
- 出版情報:
- Public Library of Science, 2014-03-20
- 著者名:
Kato, Ken-ichiro Takamura, Toshinari Takeshita, Yumie Ryu, Yasuji Misu, Hirofumi Ota, Tsuguhito Tokuyama, Kumpei Nagasaka, Shoichiro Matsuhisa, Munehide Matsui, Osamu Kaneko, Shuichi - 掲載情報:
- PLoS ONE
- ISSN:
- 1932-6203
- 巻:
- 9
- 通号:
- 3
- 開始ページ:
- e92170
- バージョン:
- publisher
- 概要:
- Objective: The aim of this study was to examine the association between ectopic fat and organ-specific insulin resistance (IR) in insulin-target organs in patients with nonalcoholic fatty liver disease (NAFLD). Methods: Organ-specific IR in the liver (hepatic glucose production (HGP)6fasting plasma insulin (FPI) and suppression of HGP by insulin [%HGP]), skeletal muscle (insulin-stimulated glucose disposal [Rd]), and adipose tissue (suppression of FFA by insulin … [%FFA]) was measured in 69 patients with NAFLD using a euglycemic hyperinsulinemic clamp with tracer infusion ([6,6-2H 2]glucose). Liver fat, intramyocellular lipid (IMCL), and body composition were measured by liver biopsy, proton magnetic resonance spectroscopy, and bioelectrical impedance analysis, respectively. Results: HGPxFPI was significantly correlated with Rd (r = -0.57, P<0.001), %HGP with %FFA (r = 0.38, P<0.01), and Rd with %FFA (r = 0.27, P<0.05). Liver steatosis score was negatively associated with Rd (r = -0.47, P<0.001) as well as with HGPxFPI ( r = 0.43, P<0.001). Similarly, intrahepatic lipid was negatively associated with Rd (r = -0.32, P<0.05). IMCL was not associated with Rd (r = -0.16, P = 0.26). Fat mass and its percentage were associated with HGPxFPI (r = 0.50, P<0.001; r = 0.48, P<0.001, respectively) and Rd (r = -0.59, P<0.001; r = -0.52, P<0.001, respectively), but not with %FFA (r = -0.21, P = 0.10; r = -0.001, P = 0.99, respectively). Conclusion: Unexpectedly, fat accumulation in the skeletal muscle and adipose tissue was not associated with organ-specific IR. Instead, liver fat was associated not only with hepatic IR but also with skeletal muscle IR, suggesting a central role of fatty liver in systemic IR and that a network exists between liver and skeletal muscle. © 2014 Kato et al. 続きを見る
- URL:
- http://hdl.handle.net/2297/37643
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Massachusetts Medical Society | |
Public Library of Science | |
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