Synthesis of a peptide lactone, N (3 hydroxypicolinyl) threonyl D leucyl prolylsarcosyl leucyl alanyl alanine threonine lactone

Synthesis of a peptide lactone, N (3 hydroxypicolinyl) threonyl D leucyl prolylsarcosyl leucyl alanyl alanine threonine lactone

フォーマット:

論文

責任表示:

Kinoshita, Hideki ; Hiroshi Kotake

言語:

英語

出版情報:

The Chemical Society of Japan = 日本化学会, 1977-01-01

著者名:

掲載情報:

Bulletin of the Chemical Society of Japan

ISSN:

0009-2673

巻:

50

通号:

1

開始ページ:

280

終了ページ:

284

バージョン:

publisher

概要:

The synthesis of a peptide lactone, N-(3-hydroxypicolinyl)-threonyl-D-leucyl-prolylsarcosyl-leucyl-alanyl-alanine Threonine Lactone (21) is described. The t-butoxycarbonyl group of t-butyl O-(t-butoxycarbonyl-alanyl)-N-benzyloxycarbonyl-threonyl-D-leucyl-prolylsarcosinate (12) was deblocked selectively with formic acid in good yield. The coupling of 12 with the azide derived from t-butoxycarbonyl-leucyl-alanine hydrazide (15) … with isopentyl nitrite gave a heptapeptide ester 17. Deblocking, cyclization, and hydrogenation gave a heptapeptide lactone 20 which was coupled with 3-hydroxypicolinic acid yielding 21. 続きを見る

URL:

http://hdl.handle.net/2297/38256

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詳細

受理日:	1977-01-01

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