Rapid proliferation of activated lymph node CD4+ T cells is achieved by greatly curtailing the duration of gap phases in cell cycle progression

フォーマット:

論文

責任表示:

Mishima, Takuya ; Toda, Shoko ; Ando, Yoshiaki ; Matsunaga, Tsukasa ; Inobe, Manabu

言語:

英語

出版情報:

Springer Verlag, 2014-01-01

著者名:

• Mishima, Takuya
• Toda, Shoko
• Ando, Yoshiaki
• Matsunaga, Tsukasa
• Inobe, Manabu

掲載情報:

Cellular and Molecular Biology Letters

ISSN:

1425-8153      

巻:

19

通号:

4

開始ページ:

638

終了ページ:

648

バージョン:

author

概要:

Peripheral T cells are in G0 phase and do not proliferate. When they encounter an antigen, they enter the cell cycle and proliferate in order to initiate an active immune response. Here, we have determined the first two cell cycle times of a leading population of CD4+ T cells stimulated by PMA plus ionomycin in vitro. The first cell cycle began around 10 h after stimulation and took approximately 16 h. Surprisingly, the second cell cycle was extremely rapid and … required only 6 h. T cells might have a unique regulatory mechanism to compensate for the shortage of the gap phases in cell cycle progression. This unique feature might be a basis for a quick immune response against pathogens, as it maximizes the rate of proliferation.<br />In Press 続きを見る

URL:

http://hdl.handle.net/2297/40602