Crucial Involvement of the CCR2/CCL2 Interactions in Azoxymethane/Dextran Sodium Sulfate-induced Colon Carcinogenesis in Mice

フォーマット:

論文

責任表示:

Popivanova, Boryana K. ; Kostadinova, Feodora I. ; Mukaida, Naofumi

言語:

英語

出版情報:

Birkhauser Verlag AG / Springer Verlag, 2014-01-01

著者名:

• Popivanova, Boryana K.
• Kostadinova, Feodora I.
• Mukaida, Naofumi

掲載情報:

Inflammation Research

ISSN:

1023-3830      

巻:

58

通号:

2

開始ページ:

S229

終了ページ:

S233

バージョン:

author

概要:

Azoxymethane (AOM) administration followed by repetitive dextran sulfate sodium (DSS) ingestion causes chronic colonic inflammation with macrophage infiltration and enhanced expression of a macrophage-tropic chemokine, CCL2, in wild-type (WT) mice. These mice eventually develop multiple colon tumors. In contrast, mice deficient in CCR2, a specific receptor for CCL2, exhibited less macrophage infiltration and attenuated tumor formation. WT mice transplanted with … CCR2-deficient bone marrow developed fewer tumors after AOM and DSS treatment than either WT or CCR2-deficient mice transplanted with WT bone marrow. Furthermore, when injected to WT mice with multiple colon tumors, a CCL2 antagonist expression vector attenuated macrophage and granulocyte infiltration, and eventually reduced the numbers and sizes of tumors. These results implied the crucial involvement of the CCL2-CCR2 interactions in the development and progression of colon carcinoma associated with chronic inflammation. 続きを見る

URL:

http://hdl.handle.net/2297/40608